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董光辉 教授
职  称: 教授(博士生导师) \

所属部门: 预防医学系

电子邮件: donggh5@mail.sysu.edu.cn  
     donggh512@hotmail.com 

现任职务:  院长助理/学科带头人.

研究方向(主要研究领域)


环境流行病学
环境毒理学


学术简历

1994.09-1999.07  中国医科大学  预防医学系预防医学专业      学士学位
2001.09-2004.07  中国医科大学  劳动卫生与环境卫生学专业    硕士学位
2006.09-2009.07  中国医科大学  劳动卫生与环境卫生学专业    博士学位
2004.07-2005.06  中国医科大学公共卫生学院                      助教
2005.07-2008.06  中国医科大学公共卫生学院                      讲师
2008.07-2013.07  中国医科大学公共卫生学院                      副教授/博士生导师
2010.08-2011.01  国立台湾大学公共卫生学院                      访问学者
2011.08-2012.09  美国圣路易斯大学公共卫生学院              访问学者
2012.12-2015.12  美国圣路易斯大学公共卫生学院              客座副教授
2013.07-2014.03  中国医科大学公共卫生学院                      教授/博士生导师
2014/03-至今     中山大学“百人计划”引进人才                  教授/博士生导师

  长期从事大气污染健康危害评价及其颗粒物主要内聚成分的毒理学研究。通过现场流行病学调查量化大气污染对人群健康危害的剂量-效应关系;结合临床病例-对照研究明确了大气颗粒物主要内聚有机毒性组分与人群健康损伤的内在关系;探讨了颗粒物新型持久性有机组分PFAAs诱导机体产生毒性效应的机制;形成了从宏观到微观、人群现场调查与实验室基础研究相结合的特色。

社会兼职

1. 2015年     International Journal of Hypertension 客座主编
2. 2015年     Journal of Epidemiology Research 编委
3. 2014年     Frontiers in Public Health 编委
4. 2014年     Archives in Public Health 编委
5. 2014年     Austin Journal of Environmental Toxicology 编委
6. 2014年     广东省环境诱变剂学会 理事
7. 2013年     中国毒理学会生化与分子专业委员会 委员

主要承担或参与的课题(5-6项代表性课题)

1、国家重点研发计划试点专项(青年)项目:基于空间分析模型和生物监测当量构建大气污染急性健康危害的预警预测体系和干预策略(批准号:2016YFC0207000)。起始时间:2016.07-2019.06。
2、国家自然科学基金项目:全氟辛烷磺酸(PFOS)诱导机体哮喘的机理研究(批准编号:81472936),起始时间:2015.01-2018.12。
3、国家自然科学基金项目:Treg在全氟辛烷磺酸(PFOS)免疫毒性效应中调控Th应答及其信号转导途径的机理研究(批准号:81172630),起始时间:2012.01-2015.12。
4、国家自然科学基金项目:全氟辛烷磺酸(PFOS)免疫毒性及机理研究(批准号:20707041),起始时间:2008.01-2010.12。
5、广东省协同创新与平台环境建设专项资金国际合作项目:大气颗粒物PM2.5及其内聚成分对人群心脑血管疾病的影响效应及其分子机制研究(批准号:1431520600005)。起始时间:2016.01-2018.12。
6、广东省自然科学基金:CD4+T细胞介导的免疫平衡在全氟辛烷磺酸(PFOS)诱导机体哮喘倾向中的作用机理(批准编号:2014A030313021),起始时间:2015.01-2017.12。

近期发表的主要文章(可以限定在近五年)

 仅第一作者和通讯作者文章
1. Qin XD, Qian Z, Dharmage SC, Perret J, Geiger SD, Rigdon SE, Howard S, Zeng XW, Hu LW, Yang BY, Zhou Y, Li M, Xu SL, Bao WW, Zhang YZ, Yuan P, Wang J, Zhang C, Tian YP, Nian M, Xiao X, Chen W, Lee LY*, Dong GH*. Association of perfluoroalkyl substances exposure with impaired lung function in children. Environmental Research 2017; 155:15-21. (IF=3.088)
2. Hu LW, Chen S, Yang M, Shah K, Hailegiorgis Y, Burgens R, Vaughn M, Huang J, Pamela X, Paul G, Morawska L, Lu T, Lin S, Zhong SQ, Kong ML, Xie YQ, Hao YT, Zeng XW, Qian Z*, Dong GH*. Effects of In Utero and Environmental Tobacco Smoke Exposure on Lung Function, by Gender and Asthma Status: the Seven Northeastern Cities (SNEC) Study. Respiration 2017; DOI: 10.1159/000455140 (IF=2.651)
3. Xu SL, Trevathan E, Qian Z, Vivian E, Yang BY, Hu LW, Zeng XW, Li M, Zhou Y, Qin XD, Bao WW, Yuan P, Zhang YZ, Wang J, Zhang C, Tian YP, Nian M, Xiao X, Dong GH*. Prenatal and postnatal exposure to pet ownership, blood pressure and hypertension in children: the Seven Northeastern Cities study. Journal of Hypertension 2017; 35(2):259-265 (IF=5.062)
4. Chen X, Zhang LW, Huang JJ, Song FJ, Zhang LP, Qian ZM, Trevathan E, Mao HJ, Han B, Vaughn M, Chen KX, Liu YM, Chen J, Zhao BX, Jiang GH, Gu Q, Bai ZP, Dong GH*, Tang NJ*. Long-term exposure to urban air pollution and lung cancer mortality: a 12-year cohort study in Northern China. Science of the Total Environment 2016; 571:855-61. (IF=3.976)
5. Zhou Y, Hu LW, Qian ZM, Chang JJ, King C, Paul G, Lin S, Chen PC, Lee YL*, Dong GH*. Association of Perfluoroalkyl substances exposure with reproductive hormone levels in adolescents: by sex status. Environment International 2016; 94:189-195. (IF=5.929)
6. Zeng XW, Vivian E, Mohammed KA, Jakhar S, Vaughn M, Huang J, Zelicoff A, Xaverius P, Bai Z, Lin S, Hao YT, Paul G, Morawska L, Wang SQ, Qian Z*, Dong GH*. Long-term ambient air pollution and lung function impairment in Chinese children from a high air pollution range area: The Seven Northeastern Cities (SNEC) Study. Atmospheric Environment 2016; 138:144-151. (IF=3.459)
7. Zhu Y, Qin XD, Zeng XW, Paul G, Morawska L, Su MW, Tsai CH, Wang SQ, Lee YL*, Dong GH*. Associations of serum perfluoroalkyl acid levels with T-helper cell-specific cytokines in children: By gender and asthma status. Science of the Total Environment 2016; 559:166-173. (IF=3.976)
8. Zhong SQ, Chen ZX, Kong ML, Xie YQ, Zhou Y, Qin XD, Gunther Paul, Zeng XW, Dong GH*. Testosterone-Mediated Endocrine Function and TH1/TH2 Cytokine Balance after Prenatal Exposure to Perfluorooctane Sulfonate: By sex Status. International Journal of Molecular Sciences 2016; 17(9):1509. (IF=3.257)
9. Qin XD, Qian Z, Vaughn MG, Huang J, Ward P, Zeng XW, Zhou Y, Zhu Y, Yuan P, Li M, Bai Z, Paul G, Hao YT, Chen W, Chen PC, Dong GH*, Lee YL*. Positive associations of serum perfluoroalkyl substances with uric acid and hyperuricemia in children from Taiwan. Environmental Pollution 2016; 212:519-524. (IF=4.839)
10. Liu YQ, Qian Z, Wang J, Lu T, Lin S, Zeng XW, Liu RQ, Zhu Y, Qin XD, Yuan P, Zhou Y, Li M, Hao YT, Dong GH*. Breastfeeding modifies the effects of environment tobacco smoke (ETS) exposure on respiratory diseases and symptoms in Chinese children: the Seven Northeast Cities (SNEC) Study. Indoor Air 2016; 26(4):614-622. (IF=4.33)
11. Meng Li, Zhengmin Qian, Michael Vaughn, Brian Boutwell, Patrick Ward, Tao Lu, Shao Lin, Yang Zhao, Xiao-Wen Zeng, Ru-Qing Liu, Xiao-Di Qin, Yu Zhu, Wen Chen, Guang-Hui Dong*. Sex-specific difference of the association between ambient air pollution and the prevalence of obesity in Chinese adults from a high pollution range area: 33 Communities Chinese Health Study. Atmospheric Environment 2015; 117:227-233. (IF=3.459)
12. Qin XD, Qian Z, Vaughn MG, Trevathan E, Emo B, Paul G, Ren WH, Hao YT, Dong GH*. Gender-specific differences of interaction between obesity and air pollution on stroke and cardiovascular diseases in Chinese adults from a high pollution range area: A large population based cross sectional study. Science of Total Environment 2015; 529:243-248. (IF=3.189)
13. Dong GH*, Wang J, Zeng XW, Chen L, Qin XD, Zhou Y, Li M, Yang M, Zhao Y, Ren WH, Hu QS*. Interactions between Air pollution and Obesity on Blood Pressure and Hypertension in Chinese Children. Epidemiology 2015; 26(5):740-747. (IF=6.075)
14. Bao J, Zeng XW, Qin XD, Lee YL, Chen X, Jin YH, Tang NJ*, Dong GH*. Phthalate Metabolites in Urine Samples from School Children in Taipei, Taiwan. Archives of Environmental Contamination and Toxicology 2015; 69(2): 202-207. (IF=2.039)
15. Zeng XW, Qian Z, Emo B, Vaughn M, Bao J, Qin XD, Zhu Y, Li J, Lee YL*, Dong GH*. Association of polyfluoroalkyl chemical exposure with serum lipids in children. Science of Total Environment 2015; 512-513:364-370. (IF=3.163).
16. Ma YN, Qian Z, Wang J, Rodemich E, Lee YL, Lv XF, Liu YQ, Zhao Y, Huang MM, Liu Y, Sun J, He QC*, Dong GH*. Environmental tobacco smoke exposure, urine CC-16 levels, and asthma outcomes among Chinese children. Allergy 2015; 70(3):295-301. (IF=5.995)
17. Zeng XW, Qian Z, Vaughn M, Xian H, Elder K, Rodemich E, Bao J, Jin YH, Dong GH*. Human serum levels of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in Uyghurs from Sinkiang-Uighur Autonomous Region, China: background levels study. Environmental Science and Pollution Research International 2015; 22(6):4736-4746. (IF=2.757)
18. Dong GH*, Qian ZM, Trevathan E, Zeng XW, Vaughn MG, Wang J, Zhao Y, Liu YQ, Ren WH, Qin XD. Air pollution associated hypertension and increased blood pressure may be reduced by breastfeeding in Chinese children: the Seven Northeastern Cities Chinese Children's Study. International Journal of Cardiology 2014; 176(3):956-961. (IF=6.175)
19. Liu F, Zhao Y, Liu YQ, Liu Y, Sun J, Huang MM, Liu Y*, Dong GH*. Asthma and asthma related symptoms in 23,326 Chinese children in relation to indoor and outdoor environmental factors: the Seven Northeastern Cities (SNEC) Study. Science of Total Environment 2014; 497-498C:10-17. (IF=3.163)
20. Huang MM, Qian Z, Wang J, Vaughn MG, Lee YL, Dong GH*. Validation of the sleep disturbance scale for children and prevalence of parent-reported sleep disorder symptoms in Chinese children. Sleep Medicine 2014; 15(8):923-8. (IF=3.10)
21. Bao J, Lee YL, Chen PC, Jin YH, Dong GH*. Perfluoroalkyl acids in blood serum samples from children in Taiwan. Environmental Science and Pollution Research 2014; 21(12):7650-7655. (IF=2.757)
22. Wang D, Qian Z, Wang J, Yang M, Lee YL, Liu F, Liu MM, Zhao Y, Liu YQ, Huang MM, Liu Y, Sun J, Liu YZ, Wu CC, Dong GH*. Gender-specific differences in associations of overweight and obesity with asthma and asthma-related symptoms in 30 056 children: results from 25 districts of Northeastern China. Journal of Asthma 2014; 51(5):508-514. (IF=1.828)
23. Dong GH, Qian ZM*, Wang J, Trevathan E, Liu MM, Wang D, Ren WH, Chen W, Simckes M, Zelicoff A. Home renovation, family history of atopy, and respiratory symptoms and asthma among children living in China. American Journal of Public Health 2014; 104(10):1920-1927. (IF=4.229)
24. Zhengmin (Min) Qian, Guang-Hui Dong*, Wan-Hui Ren, Maayan Simckes, Jing Wang, Alan Zelicoff, Edwin Trevathan. Effect of pet ownership on respiratory responses to air pollution in Chinese children: The Seven Northeastern Cities (SNEC) study. Atmospheric Environment 2014; 87:47-52. (IF=3.062).
25. Guang-Hui Dong, Zhengmin (Min) Qian*, Miao-Miao Liu, Da Wang, Wan-Hui Ren, Louise H. Flick, John Fu, Jing Wang, Weiqing Chen, Maayan Simckes, Edwin Trevathan. Ambient air pollution and the prevalence of obesity in chinese children: The seven northeastern cities study. Obesity 2014; 22(3):795-800. (IF=4.389)
26. Dong GH, Qian Z*, Fu Q, Wang J, Trevathan E, Ma W, Liu MM, Wang D, Ren WH, Ong KH, Ferguson TF, Riley E, Simckes M. A Multiple Indicators Multiple Cause (MIMIC) model of respiratory health and household factors in Chinese children: the seven Northeastern cities (SNEC) study. Maternal and Child Health Journal 2014; 18(1):129-137. (IF=2.015)
27. Zhao Y, Qian ZM, Wang J, Vaughn MG, Liu YQ, Ren WH, Dong GH*. Does obesity amplify the association between ambient air pollution and increased blood pressure and hypertension in adults? Findings from the 33 Communities Chinese Health Study. International Journal of Cardiology 2013; 168(5):e148-e150. (IF=6.175)
28. Dong GH, Qian ZM*, Wang J, Trevathan E, Ma W, Chen W, Xaverius PK, Buckner-Petty S, Ray A, Liu MM, Wang D, Ren WH, Emo B, Chang JJ. Residential characteristics and household risk factors and respiratory diseases in Chinese women: the Seven Northeast Cities (SNEC) study. Science of the Total Environment 2013; 463-464:389-394. (IF=3.163)
29. Liu MM, Wang D, Zhao Y, Liu YQ, Huang MM, Liu Y, Sun J, Ren WH, Zhao YD, He QC, Dong GH*. Effects of outdoor and indoor air pollution on respiratory health of Chinese children from 50 kindergartens. Journal of Epidemiology 2013; 23(4):280-287. (IF=2.862)
30. Guang-Hui Dong, Zhengmin (Min) Qian*, Jing Wang, Weiqing Chen, Wenjun Ma, Edwin Trevathan, Pamela K. Xaverius, Richard DeClue, Andrew Wiese, Marvin Langston, Miao-Miao Liu, Da Wang, Wan-Hui Ren. Association between ambient air pollution and prevalence of stroke and cardiovascular diseases in 33 Chinese communities. Atmospheric Environment 2013; 77:968-973. (IF=3.062)
31. Ma YN, Wang J, Dong GH*, Liu MM, Wang D, Liu YQ, Zhao Y, Ren WH, Lee YL, Zhao YD, He QC*. Predictive equations using regression analysis of pulmonary function for healthy children in Northeast China. PLoS One 2013; 8(5):e63875. (IF=3.534)
32. Dong GH, Qian ZM*, Liu MM, Wang D, Ren WH, Bawa S, Fu J, Wang J, Lewis R, Zelicoff A, Simckes M, Trevathan E. Breastfeeding as a modifier of the respiratory effects of air pollution in children. Epidemiology 2013; 24(3):387-394. (IF=6.178)
33. Deng WW*, Wang J, Liu MM, Wang D, Zhao Y, Liu YQ, Wang H, Dong GH*. Body mass index compared with abdominal obesity indicators in relation to prehypertension and hypertension in adults: the CHPSNE Study. American Journal of Hypertension 2013; 26(1):58-67. (IF=3.402)
34. Dong GH, Qian ZM*, Xaverius PK, Trevathan E, Maalouf S, Parker J, Yang L, Liu MM, Wang D, Ren WH, Ma W, Wang J, Zelicoff A, Fu Q, Simckes M. Association between long-term air pollution and increased blood pressure and hypertension in China. Hypertension 2013; 61(3):578-584. (IF=7.632)
35. Dong GH, Tung KY, Tsai CH, Liu MM, Wang D, Liu W, Jin YH, Hsieh WS, Lee YL*, Chen PC. Serum polyfluoroalkyl concentrations, asthma outcomes, and immunological markers in a case-control study of Taiwanese children. Environmental Health Perspectives 2013; 121(4):507-513. (IF=7.029)
36. Zhang YH, Wang J, Dong GH*, Liu MM, Wang D, Zheng L, Jin YH. Mechanism of perfluorooctanesulfonate (PFOS)-induced apoptosis in the immunocyte. Journal of Immunotoxicology 2013; 10(1):49-58. (IF=1.907)
37. Dong GH, Qian Z*, Liu MM, Wang D, Ren WH, Fu Q, Wang J, Simckes M, Ferguson TF, Trevathan E. Obesity enhanced respiratory health effects of ambient air pollution in Chinese children: the Seven Northeastern Cities study. International Journal of Obesity 2013; 37(1):94-100. (IF=5.386)
38. Dong GH*, Wang J, Zhang YH, Liu MM, Wang D, Zheng L, Jin YH. Induction of p53-mediated apoptosis in splenocytes and thymocytes of C57BL/6 mice exposed to perfluorooctane sulfonate (PFOS). Toxicology and Applied Pharmacology 2012; 264(2):292-299. (IF=3.975)
39. Dong GH*, Wang J, Liu MM, Wang D, Lee YL, Zhao YD. Allergic predisposition modifies the effects of pet exposure on respiratory disease in boys and girls: the seven northeast cities of China (SNECC) study. Environmental Health 2012; 11:50. (IF=2.714)
40. Meng XJ, Dong GH*, Wang D, Liu MM, Liu YQ, Zhao Y, Deng WW, Tian S, Meng X, Zhang HY. Epidemiology of prehypertension and associated risk factors in urban adults from 33 communities in China--the CHPSNE study. Circulation Journal 2012; 76(4): 900-906. (IF=3.578)
41. Dong GH*, Wang D, Liu MM, Liu YQ, Zhao Y, Yang M, Meng XJ, Tian S, Meng X, Zhang HY. Sex difference of the prevalence and risk factors associated with prehypertension among urban Chinese adults from 33 communities of China: the CHPSNE study. Journal Hypertension 2012; 30(3): 485-491. (IF=3.806)
42. Dong GH, Zhang P, Sun B, Zhang L, Chen X, Ma N, Yu F, Guo H, Huang H, Lee YL, Tang N, Chen J*. Long-term exposure to ambient air pollution and respiratory disease mortality in Shenyang, China: a 12-year population-based retrospective cohort study. Respiration 2012; 84(5):360-368. (IF=2.615)
43. Dong GH*, Zhang YH, Zheng L, Liang ZF, Jin YH*, He QC. Subchronic effects of perfluorooctanesulfonate exposure on inflammation in adult male C57BL/6 mice. Environmental Toxicology 2012; 27(5): 285-296. (IF=2.708)
44. Ma YN, Chen T, Wang D, Liu MM, He QC*, Dong GH*. Prevalence of overweight and obesity among preschool children from six cities of northeast China. Archives of Medical Research 2011; 42(7):633-640. (IF=1.733)
45. Dong GH*, Chen T, Liu MM, Wang D, Ma YN, Ren WH, Lee YL*, Zhao YD, He QC*. Gender difference and effects of air pollution on asthma in children with and without allergic predisposition: northeast Chinese children health study. PLoS ONE 2011; 6(7):e22470. (IF=4.092)
46. Tian S, Dong GH*, Wang D, Liu MM, Lin Q, Meng XJ, Xu LX, Hou H, Ren YF. Factors associated with prevalence, awareness, treatment and control of hypertension in urban adults from 33 communities in China: the CHPSNE Study. Hypertens Res 2011; 34(10):1087-92
47. Zhang P†, Dong G†, Sun B, Zhang L, Chen X, Ma N, Yu F, Guo H, Huang H, Lee YL, Tang N, Chen J*. Long-term exposure to ambient air pollution and mortality due to cardiovascular disease and cerebrovascular disease in shenyang, China. PLoS ONE 2011; 6(6):e20827. (IF=4.092)(†并列第一作者)
48. Meng XJ, Dong GH*, Wang D, Liu MM, Lin Q, Tian S, Xu LX, Hou H, Ren YF, Lee YL. Prevalence, awareness, treatment, control, and risk factors associated with hypertension in urban adults from 33 communities of China: the CHPSNE Study. Journal of Hypertension 2011; 29(7):1303-1310. (IF=4.021)
49. Dong GH*, Wang D, Yang ZH, Zhang PF, Ren WH, Zhao YD, He QC*. Gender-specific differences in effects of prenatal and postnatal environmental tobacco smoke exposure on respiratory symptoms in 23,474 children with and without allergic predisposition: results from 25 districts of northeast China. International Journal of Environmental Health Research 2011; 21(3):173-188. (IF=0.864)
50. Dong GH*, Liu MM, Wang D, Zheng L, Liang ZF, Jin YH*. Sub-chronic effect of perfluorooctanesulfonate (PFOS) on the balance of type 1 and type 2 cytokine in adult C57BL6 mice. Archives of Toxicology 2011; 85(10): 1235-1244. (IF=4.674)
51. Zheng L, Dong GH*, Zhang YH, Liang ZF, Jin YH*, He QC. Type 1 and Type 2 cytokines imbalance in adult male C57BL/6 mice following a 7-day oral exposure to perfluorooctanesulfonate (PFOS). Journal of Immunotoxicology 2011; 8(1):30-38. (IF=1.439)
52. Dong GH*, Ren WH, Wang D, Yang ZH, Zhang PF, Zhao YD, He QC*. Exposure to secondhand tobacco smoke enhances respiratory symptoms and responses to animals in 8,819 children in kindergarten: results from 25 districts in northeast China. Respiration 2011; 81(3):179-185. (IF=2.258) 

研究生培养情况

在读博士生:2名
在读硕士生:4名
已毕业硕士生:7名

招生专业

环境卫生与劳动卫生学
公共卫生硕士(MPH)

获奖情况

董光辉、马亚楠、张鹏飞、马楠楠、于飞、黄辉、郭慧敏。出生前后暴露PFOS对小鼠免疫发育功能的影响及机理研究。辽宁省教育厅优秀科学研究成果奖(成果登记号:辽教科结第LJ2012611),2013年3月。

张海燕、孟欣、都镇先、王华芹、邓娓娓、董光辉、刘国良、徐景春、齐国先。内质网应激、氧化应激和整合应激在甲状腺肿瘤靶向治疗中的作用,辽宁省科学技术奖,二等奖(证书号:2013J-2-55-06),2013年12月。

张海燕、孟欣、都镇先、王华芹、邓娓娓、董光辉、刘国良、徐景春、齐国先。内质网应激、氧化应激和整合应激在甲状腺肿瘤靶向治疗中的作用,沈阳市科学技术进步奖二等奖(证书号:2013-2-41-8)。2013年9月。