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韦艳宏
职  称: 教授\(博士生导师)

所属部门: 预防医学系

电子邮件: weiyh9@mail.sysu.edu.cn 
     

研究方向(主要研究领域)


环境暴露的健康效应
心血管毒理学
发育毒理学


学术简历


1997 - 2002   华中科技大学同济医学院,预防医学,学士
2002 - 2005   华中科技大学同济医学院,卫生毒理学,硕士
2005 - 2008   中国科学院动物研究所,生态毒理学,博士
2008 - 2015   美国约翰霍普金斯大学医学院,博士后
2015 - 2016   美国约翰霍普金斯大学医学院,副研究员
2016 - 至今   中山大学“百人计划”引进人才,教授/博士生导师
 
社会兼职

杂志审稿人:
Archives of Toxicology    
Toxicology Letters    
Aquatic Toxicology    
Toxicology In Vitro    
Ecotoxicology and Environmental Safety    
Journal of Proteome Research             
Scientific Reports
Marine Environmental Research    
Journal of Toxicology and Environmental Health     
学会会员:
Society of Toxicology
The Association for Research in Vision and Ophthalmology

主要承担或参与的课题

1. 中山大学“百人计划”项目,2016-2021
2. 美国National Institute of Health资助项目,5R01EY022383,Regulation of diabetic retinopathy by Nrf2,2012-2020,参与(主要执行者)
3. 美国National Institute of Health资助项目,5R01EY022683,Role of Nrf2 in retinal vascularization and ROP,2012-2016,参与(主要执行者)
4. 国际Juvenile Diabetes Research Foundation资助项目,Targeting of PKD1-HDAC in proliferative diabetic retinopathy,2011-2013,参与
5. 美国Charitable Leadership Foundation-Medical Technology Acceleration Program资助项目,Treatment of Retinal Neovascularization with Tetrac and Tetrac Nanoparticle,2009-2011,参与
6. 美国Knights Templar Eye Foundation资助项目,Regulation of Retinal Neovascularization in ROP by FoxO Transcription Factors,2009-2010,主持

近期发表的主要文章

1. Wei Y, Gong J, Xu Z, Duh E. Nrf2 promotes reparative angiogenesis through regulation of NADPH oxidase-2 in oxygen-induced retinopathy. Free Radic. Biol. Med. 2016, 99: 234-243.
2. Wei Y, Gong J, Xu Z, Thimmulappa, R, Mitchell K, Welsbie D, Biswal S, Duh E. Nrf2 in ischemic neurons promotes retinal vascular regeneration through regulation of Semaphorin 6A. Proc. Natl. Acad. Sci. U.S.A. 2015, 112: E6927-6936. (Reported in World News)
3. Huang H, He J, Johnson D, Wei Y, Liu Y, Wang S, Lutty GA, Duh E, Semba RD. Deletion of placental growth factor prevents diabetic retinopathy and is associated with Akt activation and HIF1α-VEGF pathway inhibition. Diabetes. 2015, 64: 200-212.
4. Xu Z, Cho H, Hartsock M, Mitchell KL, Gong J, Wu L, Wei Y, Wang S, Thimmulappa RK, Sporn MB, Biswal S, Welsbie DS, and Duh E.  Neuroprotective role of Nrf2 for retinal ganglion cells in ischemia reperfusion. J Neurochem. 2015, 133: 233-241.
5. Wei Y, Gong J, Thimmulappa, R, Kosmider B, Biswal S, Duh E. Nrf2 acts cell-autonomously in endothelium to regulate tip cell formation and vascular branching. Proc. Natl. Acad. Sci. U.S.A. 2013, 110: E3910-3918. (Highlighted in Editors' Choice section of Science Signaling)
6. Xu Z, Wei Y, Gong J, Cho H, Park JK, Sung ER, Huang H, Wu L, Eberhart C, Handa JT, Du Y, Kern TS, Thimmulappa R, Barber AJ, Biswal S, Duh E. NRF2 plays a protective role in diabetic retinopathy in mice. Diabetologia 2013, 57: 204-213.
7. Yoshida T, Gong J, Xu Z, Wei Y, Duh E. Inhibition of pathological retinal angiogenesis by the integrin αvβ3 antagonist tetraiodothyroacetic acid (tetrac). Exp. Eye Res. 2012, 94: 41-48.
8. Wei Y, Gong J, Yoshida T, Eberhart C, Xu Z, Kombairaju P, Sporn M, Handa J, Duh E. Nrf2 has a protective role against neuronal and capillary degeneration in retinal ischemia–reperfusion injury. Free Radic. Biol. Med. 2011, 51: 216-224.
9. Huang H, Gandhi J, Zhong X, Wei Y, Gong J, Duh E, Vinores S. TNFalpha is required for late BRB breakdown in diabetic retinopathy, and its inhibition prevents leukostasis and protects vessels and neurons from apoptosis. Invest. Ophthalmol. Vis. Sci. 2011, 52: 1336-1344.
10. Fang X, Wei Y, Liu Y, Wang J, Dai J. The identification of apolipoprotein genes in rare minnow (Gobiocypris rarus) and their expression following perfluorooctanoic acid exposure. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2010, 151: 152-159.
11. Wei Y, Shi X, Zhang H, Wang J, Zhou B, Dai J. Combined effects of polyfluorinated and perfluorinated compounds on primary cultured hepatocytes from rare minnow (Gobiocypris rarus) using toxicogenomic analysis. Aquat. Toxicol. 2009, 95: 27-36.
12. Wei Y, Chan LL, Wang D, Zhang H, Wang J, Dai J. Proteomic analysis of hepatic protein profiles in rare minnow (Gobiocypris rarus) exposed to perfluorooctanoic acid. J. Proteome Res. 2008, 7:1729-1739.
13. Wei Y, Liu Y, Wang J, Tao Y, Dai J. Toxicogenomic analysis of the hepatic effects of perfluorooctanoic acid on rare minnows (Gobiocypris rarus). Toxicol. Appl. Pharmacol. 2008, 226: 285-297. (Highlighted as a cover article)
14. Liu Y, Wang J, Wei Y, Zhang H, Liu Y, Dai J. Molecular characterization of cytochrome P450 3A and 1A and the effects of perfluorooctanoic acid on their mRNA levels in rare minnow (Gobiocypris rarus) gills. Aquat. Toxicol. 2008, 88:183-190.
15. Liu Y, Wang J, Wei Y, Zhang H, Xu M, Dai J. Induction of time-dependent oxidative stress and related transcriptional effects of perfluorododecanoic acid in zebrafish liver. Aquat. Toxicol. 2008, 89: 242-250.
16. Zhang H, Shi Z, Liu Y, Wei Y, Dai J. Lipid homeostasis and oxidative stress in the liver of male rats exposed to perfluorododecanoic acid. Toxicol. Appl. Pharmacol. 2008, 227: 16-25.
17. Wang J, Wei Y, Wang D, Chan LL, Dai J. Proteomic study of the effects of complex environmental stresses in the livers of goldfish (Carassius auratus) that inhabit Gaobeidian Lake in Beijing, China. Ecotoxicology 2008, 17: 213-220.
18. Wei Y, Dai J, Liu M, Wang J, Xu M, Zha J, Wang Z. Estrogen-like properties of perfluorooctanoic acid as revealed by expressing hepatic estrogen-responsive genes in rare minnows (Gobiocypris rarus). Environ. Toxicol. Chem. 2007, 26: 2440-2447.
19. Wei Y, Wang J, Zhang X, Xu M, Dai J. Identification and characterization of expressed sequence tags from the liver of rare minnow (Gobiocypris rarus). Comp. Biochem. Physiol. Part D Genomics Proteomics 2007, 2: 356-362.
20. Wang J, Wei Y, Li X, Cao H, Xu M, Dai J. The identification of heat shock protein genes in goldfish (Carassius auratus) and their expression in a complex environment in Gaobeidian Lake, Beijing, China. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2007, 145: 350-362.
21. Wang J, Wei Y, Li X, Xu M, Dai J. Identification of differentially expressed genes from contaminant and thermal exposed goldfish Carassius auratus in Gaobeidian Lake in Beijing, China. Ecotoxicology 2007, 16: 525-532. 

招生专业

卫生毒理学
公共卫生硕士(MPH)

获奖情况

中国科学院优秀毕业生
“朱李月华”优秀博士奖学金
华中科技大学优秀毕业生