联系我们
  • 电话:8620-87330678
  • 传真:020-87330446
  • 招生热线:020-87335498
  • 地址:广东广州中山二路74号
  • 网址:sph.sysu.edu.cn
杨丽丽
职  称: 杨丽丽(博士生导师) \

所属部门: 营养学系

电子邮件: yangll7@mail.sysu.edu.cn


研究方向(主要研究领域)


脂肪肝、肝纤维化防治

学术简历

1. 教育背景
1997年毕业于哈尔滨医科大学预防医学系   
1999年硕士毕业于(现)中山大学营养学专业
     导师:凌文华教授(中山大学公共卫生学院)
     硕士论文: 溶血卵磷脂对泡沫巨噬细胞胆固醇外流的影响及机制
2006年营养学博士毕业于美国Case Western Reserve University School of Medicine
     导师: Dr. Henri Brunengraber, M.D., Ph.D.
     博士论文: Metabolomics and mass isotopomer study of gluoconeogenesis and citric acid cycle with 13C labeled biocarbonate and succinate (应用代谢组学和质谱学利用稳定性碳同位素标记的碳酸氢钠和琥珀酸研究糖异生和三羧酸循环)

2. 学习和工作经历
1992-1997   哈尔滨医科大学  
1997-2000   硕士研究生  中山医科大学公共卫生学院营养系
2000-2002   讲师  中山医科大学公共卫生学院预防医学系
2002-2006  博士生(PhD student), Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH
2006-2009 博士后(Postdoc Research Fellow), Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH
2010-2011  博士后/讲师(Postdoc Research Fellow/Instructor-faculty)Department of Pharmacology and Systemic Therapeutics, Mount Sinai School of Medicine, New York, NY
2011-2013.04 讲师(Instructor-faculty), Department of Pharmacology, Cornell University Weill Cornell Medical College, New York, NY
2013.04-今 教授,中山大学公共卫生学院

社会兼职

广东省脑卒中与预防康复学会常委

主要承担或参与的课题(5-6项代表性课题)

国家自然科学基金面上项目,2014/01-2017/12, 70万元,主持;
国家自然科学基金面上项目,2016/01-2019/12, 50万元,主持;
广东省自然科学基金面上项目,2015/09-2017/12, 10万元,主持;
教育部回国人员启动基金, 2015/03-2016/03, 3.5万元,主持;
中山大学重大培育项目, 2016/01-2017/12, 20万元,主持。

近期发表的主要文章(可以限定在近五年)

1. Yang, L*., Rozenfeld R., Wu, D., Devi, LA., Zhang, Z.*, and Cederbaum A*. Cannabidiol protects liver from binge alcohol-induced steatosis by mechanisms including inhibition of oxidative stress and increase in autophagy. Free Radical Biology & Medicine. 68: 260-267, 2014.
2. Ismailoglu, I., Chen, Q., Popowski, M., Yang, L., Gross, S.S. *, and Brivanlou, AH*. Huntingtin protein is essential for mitochondrial metabolism bioenergetics and structure in murine embryonic stem cells. Developmental Biology. 2014; 391: 230-240.
3. Yang, L., Wu, D., and Cederbaum, AI*. CYP2E1, oxidative stress and MAPK signaling pathway in alcohol-induced hepatotoxicyt. (Review). J of Biochem and Pharm Res.2(2):74-90, 2014 .
4.Wang, X., Wu D., Yang, L., Gan, L., Cederbaum, AI*.  CYP2E1 Potentiates Ethanol-induction of Hypoxia and HIF-1α in vivo. Free Radical Biology & Medicine. 63:175-186, 2013.
5.Wang S., Yang, L*. Mechanisms and research progresses of alcoholic fatty liver. International Liver Disease (review). 2013; 10-12-13.
6. Yang, L.*, Wu, D., Wang, X., and Cederbaum, AI*. Interactions between CYP2E1, JNK, Autophagy and oxidative stress in acute alcohol-induced fatty liver. Free Radical Biology & Medicine. 53; 1170-1180, 2012.
7.Wu, D., Wang, X., Yang, L., and Cederbaum, AI*. Role of Autophagy in the Modulation of Cytochrome P4502E1-mediated Binge Alcohol Liver Steatosis and Cytotoxicity. Free Radical
Biology & Medicine. 53(6): 1346-57, 2012.
8. Cederbaum, AI*, Yang, L., Wang, X, Wu, D. CYP2E1 sensitizes the liver to LPS and TNF-induced toxicity via elevated oxidative and nitrosative stress and activation of ASK-1 and JNK mitogen activated kiniases (review). International J of Hepatology. 2012; 2012: 582790.
9.Yang, L*., and Cederbaum, AI. Interaction of CYP2E1 and anti-oxidative stress factors in alcoholic liver disease (review). Recent Advances in Alcoholic Liver Disease, 27-45 ISBN: 978-81-7895-571-1, 2012.
10.Yang, L., Wu, D., Wand, X., and Cederbaum, AI*.. Depletion of cytosolic or mitochondrial thioredoxin increases CYP2E1 induced oxidative stress via an ASK-1-JNK1 pathway in HepG2 cells. Free Radical Biology & Medicine. 2011; 51: 185-196.
11. Wang, X., Wu, D., Yang, L., Cederbaum, AI*. Hepatotoxicity mediated induced by TNFα was mediated by JNK1 but not JNK2. Hepatology. 2011. 54(5):1753-66.
12. Yang, L., and Cederbaum, AI*.. CYP2E1, oxidative stress and MAPK signaling pathway in alcoholic liver disease (review). Research Trends- Current Topics in Toxicology. 2011(7): 1-11.
13. Yang, L., Latchoumycandane, C, McMulllen, M.R., Pratt, B.T., Zhang, R., Papouchado, B.G., Nagy, L.E., Feldstein, A.E., and McIntyre TM*.. Chronic alcohol exposure increases circulating bioactive oxidized phospholipids. J. Biol. Chem. 2010; 285(29):22211-20.

研究生培养情况

现有博士生2名,硕士生5名。

招生专业

营养与食品卫生学
公共卫生硕士(MPH)