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陈 雯
职  称: 教授(博士生导师) \

所属部门: 预防医学系

电子邮件: chenwen@mail.sysu.edu.cn  

现任职务:  

研究方向(主要研究领域)

分子与遗传毒理学

学术简历

  2005年作为人才引进受聘于中山大学公共卫生学院,长期致力于遗传毒理学和环境化学致癌机理方面的研究。获得国家杰出青年基金(2009年);主持3项国家自然科学基金重点项目;参与国家重点基础研究计划(973)项目 (2项)、863重大项目(1项)、卫生部公益项目(1项)、科技部支撑计划项目(1项)等课题的研究。2005年入选教育部“新世纪优秀人才支持计划”;2010年入选“珠江学者”特聘教授。国家重点二级学科-卫生毒理学的学科带头人;《毒理学基础》教材副主编,《中华预防医学杂志》副总编。在国内外杂志发表论文160多篇,其中SCI收录文章70多篇, 文章被引1800+次。以第1作者或通讯作者在《Cell》、《Cancer Cell》、《Cancer Res》、《Oncogene》、《Carcinogenesis》、《Toxicol Appl Pharm》、《Toxicol Sci》、《J Biol Chem》等杂志发表论著。近年来的主要研究方向是:人体细胞转化模型建立和应用;环境致癌表观遗传机制以及人群生物标记物研究;DNA损伤修复以及氧化损伤的表观遗传调控机制。

社会兼职

1. 中国毒理学会常务理事/生化与分子毒理学专业委员会主任委员
2. 中国环境诱变剂学会常务理事
3. 广东省环境诱变剂学会理事长
4. 中华预防医学卫生毒理学专业委员会副主任委员
5. 中国环境诱变剂学会抗癌抗突变专业委员会副主任委员
6.《Toxicology Research》编委
7.《中华预防医学杂志》副总编
8.《癌变·畸变·突变》杂志常务编委
9. 环保部化学物质环境管理评审专家

主要承担或参与的课题
1. 基于毒性通路的大气细颗粒物暴露致肺癌机制研究国家自然科学基金重大研究计划重点项目(课题主持人 2016-2019)
2. 职业低浓度苯暴露的血液毒性机制和毒作用模式研究 国家自然科学基金重点项目 (课题主持人 2015-2019)
3. 职业有害因素早期健康效应的检测与评估技术研究 国家科技支撑计划课     题(合作课题 2014-2018) 
4. 基于代谢酶表观遗传调控机制的细胞模型构建及应用 广东省自然科学基金重点项目 (课题主持人 2014-2016)
5. 化学致癌表观遗传调控模式研究 国家杰出青年基金(课题主持人 2010-2013)
6. 职业卫生检测与健康监护技术研究  卫生公益性行业科研专项(单元负责人 2010-2013)
7. 恶性肿瘤非编码RNA相关蛋白的功能网络与调控机制的研究国家重点基础研究计划(973)项目 (2010-2014)
8. 环境遗传毒性物质暴露和效应评估关键技术 863计划重大专项(分题负责人 2008-2011)
9. 环境化学污染物诱导细胞转化的表观遗传机制. 国家自然科学基金重点项目(课题主持人 2007-2010, 30630055)

近期发表的主要文章
1. Zhini He, Daochuan Li, Junxiang Ma, Liping Chen, Huawei Duan, Bo Zhang, Chen Gao, Jie Li, Xiumei Xing, Jian Zhao, Shan Wang, Fangping Wang, Haiyan Zhang, Huiyao Li, Shen Chen, Xiaowen Zeng, Qing Wang, Yongmei Xiao, Yuxin Zheng, Wen Chen*. TRIM36 hypermethylation is involved in polycyclic aromatic hydrocarbons-induced cell transformation. Environ Pollution, 2017; 225:93-103.
2. Lu Ma, Jun Li, Zhengbao Zhang, Liping Chen, Daochuan Li, Qing Bai, Chen Gao, Jie Li, Xiaowen Zeng, Zhine He, Shang Wang, Yongmei Xiao, Wen Chen*, Aihua Zhang*. Specific Histone Modification Responds to Arsenic-induced Oxidative Stress. Toxicol Appl Pharmacol, 2016; 302:52-61.
3. Xiaonian Zhu, Daochuan Li, Zhengbao Zhang, Wei Zhu, Wenxue Li, Jian Zhao, Xiumei Xing, Zhini He, Shan Wang, Fangping Wang, Lu Ma, Qing Bai, Xiaowen Zeng, Jie Li, Chen Gao, Yongmei Xiao, Qing Wang, Liping Chen*, and Wen Chen*. Persistent Phosphorylation at Specific H3 Serine Residues Involves in Chemical Carcinogen-induced Cell Transformation. Mol Carcinogenesis, 2016 Dec 20. doi: 10.1002/mc.22605.
4. Jie Li, Xinjie Zhang, Zhini He, Qing Sun, Fei Qin, Zhenlie Huang, Xiao  Zhang, Xin Sun, Linhua Liu, Liping, Chen Gao, Shan Wang, Fangping Wang, Daochuan Lia, Xiaowen Zeng, Qifei Deng, Qing Wang, Bo Zhang, Huanwen Tang, Wen Chen*, and Yongmei Xiao* MGMT Hypomethylation Associated with DNA Damage in Petrochemical Industry Workers Exposed to Low-dose Benzene. Biomarkers, 2016 Dec 21:1-26. doi: 10.1080/1354750X.2016.1274335.
5. Zhengbao Zhang, Liping Chen, Xiumei Xing, Daochuan Li, Chen Gao, Zhini He, Jie Li, Xiaonian Zhu, Xinhua Xiao, Shan Wang, Fangping Wang, Zefang Ren, Yongmei Xiao, Shyamali C Dharmage, Guanghui Dong, Yuxin Zheng, and Wen Chen*. Specific Histone Modifications Were Associated with PAHs-induced DNA Damage Response in Coke Oven Workers. Toxicol Res, 2016, 5, 1193-1201.
6. ZN He, HW Duan, B Zhang, M Li, LP Chen, B Zhang, XN Zhu, C Gao, J Li, X Zhang, JM Zhang, S Wang, XW Zeng, DC Li, XM Xing, ZB Zhang, L Ma, Q Bai, CX Liu, YM Xiao, YX Zheng, W Chen*. CpG Site-specific RASSF1a Hypermethylation Is Associated with Occupational PAHs Exposure And Genomic Instability. Toxicol Res, 2015; 4:848-57.
7. CX Liu, XM Xing, LP Chen, DC Li, XW Zeng, Q Wei, C Gao, ZB Zhang, JM Zhang, ZN He, L Ma, J Li, HW Duan, Q Wang, YX Zheng, YM Xiao*, and W Chen*. Specific Histone Modifications Regulates The Expression of Aryl Hydrocarbon Receptor in 16HBE Cells Exposed to Benzo(a)pyrene. Toxicol Res, 2015; 4:143-51. 
8. XN Zhu, LP Chen, Q Bai, L Ma, DC Li, JM Zhang, C Gao, ZN Lei, ZB Zhang, XM Xing, CX Liu, ZN He, J Li, YM Xiao, AH Zhang, XW Zeng* and W Chen*. PP2A-AMPK-HSF1 Axis Regulates Metal-inducible expression of HSPs and ROS Clearance. Cell Signaling, 2014; 26:825-832.
9. LP Chen, L Ma, Q Bai, XN Zhu, JM Zhang, Q Wei, DC Li, C Gao, ZB Zhang, CX Liu, ZN He, XW Zeng, AH Zhang, WD Qu, Zhixiong Zhuang, Wen Chen*, and YM Xiao*. Heavy Metal-Induced Metallothionein Expression Is Regulated by Specific Protein Phosphatase 2A Complexes. J Biol Chem, 2014; 289(32):22413-26.
10. DC Li, CX Liu, HH Yu, XW Zeng, XM Xing, LP Chen, C Gao, ZB Zhang, YM Xiao, HW Duan, YX Zheng, Q Wang,* Wen Chen. AhR Is Negatively Regulated by miR-203 in Response to TCDD or BaP Treatment. Toxicol Res, 2014,3:142.
11. Kalev P, Simicek M, Vazquez I, Munck S, Chen L, Soin T, Danda N, Chen W, Sablina A*. Loss of PPP2R2A Inhibits Homologous Recombination DNA Repair and Predicts Tumor Sensitivity to PARP Inhibition. Cancer Res, 2012; 72(24):6414-24.
12. P Yang, JX Ma, B Zhang, HW Duan, ZN He, JL Zeng, XW Zeng, DC Li, Q Wang, YM Xiao, CX Liu, Q Xiao, LP Chen, XN Zhu, XM Xing, ZF Li, SX Zhang, ZB Zhang, L Ma, EM Wang, ZX Zhuang, YX Zheng*, Wen Chen*. CpG Site-Specific Hypermethylation of p16INK4 In Peripheral Blood Lymphocytes of PAH-Exposed Workers. Cancer Epidem Biomar, 2012; 21(1):182-90.
13. DC Li, Q Wang, CX Liu, HW Duan, XW Zeng, B Zhang, XD Li, J Zhao, SF Tang, ZF Li, XM Xing, P Yang, LP Chen, JL Zeng, XN Zhu, SX Zhang, ZB Zhang, L Ma, ZN He, EM Wang, YM Xiao, YX Zheng, W Chen*. Aberrant Expression of miR-638 Contributes to Benzo(a)pyrene–induced Human Cell Transformation. Toxicol Sci, 2012; 125(2): 382-91.
14. L-P Chen, Y-D Lai, D-C Li, X-N Zhu, P Yang, W-X Li, W Zhu, J Zhao, X-D Li, Y-M Xiao, Y Zhang, X-M Xing, Q Wang, B Zhang, Y-C Lin, J-L Zeng, S-X Zhang, C-X Liu, Z-F Li, X-W Zeng, Z-N Lin, Z-X Zhuang, and W Chen*. Alpha4 Is Highly Expressed In Carcinogen-transformed Human Cells And Primary Human Cancers. Oncogene, 2011; 30(26):2943-2953.
15. Q Wang, D-C Li, Z-F Li, C-X Liu, Y-M Xiao, B Zhang, X-D Li, J Zhao, L-P Chen, X-M Xing, S-F Tang, Y-C Lin, Y-D Lai, P Yang, J-L Zeng, Q Xiao, X-W Zeng, Z-N Lin, Z-X Zhuang and W Chen*. Upregulation of miR-27a Contributes to the Malignant Transformation of Human Bronchial Epithelial Cells Induced by SV40 Small T Antigen. Oncogene, 2011; 30(36):3875-86. 32.  
16. Pang YQ, Ma RL, Li WX, Wang Q, Li DC, Xiao YM, Wei Q, Lin YC, Lai YD, Yang P, Tang S, Zhuang ZX, Zheng YX, Chen W*. Development of Human Cell Models for Assessing the Carcinogenic Potential of Chemicals. Toxicol Appl Pharm, 2008, 232:478-86.
17. Ji WD, Yang LQ, Yu L, Yuan JH, Hu DL, Zhang WJ, Yang JP, Pang YQ, Li WX, Lu JC, Fu J, Chen JK, Lin ZN, Chen W*, Zhuang ZX*. Epigenetic Silencing of O6-methylguanine-DNA Methyltransferase Gene in NiS-transformed Cells. Carcinogenesis, 2008; 29(6):1267-75.
18. Sablina AA, Chen W (co-first author), Arroyo JD, Laura Corral, Melissa Hector, Sara E. Bulmer James A. DeCaprio, and Hahn WC. The Tumor Suppressor PP2A Abeta Regulates The RalA GTPase. Cell, 2007; 129: 969-82.
19. Chen W, Arroyo JD, Timmons JC, Possemato R, and Hahn WC. Cancer-associated PP2A Aalpha Subunit Mutations Contribute to Human Cell Transformation. Cancer Res, 2005; 65(18):8183-92.
20. Chen W, Possemato R, Campbell KT, Plattner CA, Pallas DC, and Hahn WC. Identification of Specific PP2A Complexes Involved in Human Cell Transformation. Cancer Cell, 2004; 5(2):127-36.
21. Chen W, Zhou YG, Nichols J, Chung KT, Hart RW, Chou MW. Effect of Dietary Restriction on Benzo[a]pyrene Metabolic Activation and Pulmonary BaP-DNA Adduct Formation in Mouse. Drug Chem Toxicol, 1996; 19(1&2):21-39.     
22. Chen W, Nichols J, Zhou YG, Chung KT, Hart RW, Chou MW. Effect of Dietary Restriction on Glutathione S-transferase Activity Specific Toward Aflatoxin B1-8,9-epoxide. Toxicol Lett, 1995; 78:235-43.

研究生培养情况

博士生毕业18名
硕士生毕业32名

招生专业

卫生毒理学
劳动卫生与职业病

获奖情况

全国优秀科技工作者 2014年