联系我们
  • 电话:8620-87330678
  • 传真:020-87330446
  • 招生热线:020-87335498
  • 地址:广东广州中山二路74号
  • 网址:sph.sysu.edu.cn
徐琳 教授
\
职  称: 教授(博士生导师)

所属部门: 医学统计与流行病学系

电子邮件: xulin27@mail.sysu.edu.cn 

联系电话:020-87335523


研究方向(主要研究领域)

慢性非传染性疾病流行病学;孟德尔随机研究

学术简历

【学习经历】
1. 2000~2005 于中山大学预防医学系学习获得学士学位
2. 2007~2008 于香港大学公共卫生学院学习获得公共卫生学硕士学位
3. 2008~2010 于香港大学公共卫生学院学习获得哲学硕士学位
4. 2010~2012 于香港大学公共卫生学院学习获得哲学博士学位
【工作经历】
1. 2005~2007年在广东省广州市第十二人民医院任职医师
2. 2012~2014年在香港大学公共卫生学院任职博士后研究员
3. 2015~2016年在香港大学公共卫生学院任职助理教授(研究)


社会兼职

自2008年以来担任了多本重要国际科学期刊的审稿人,包括Lancet Diabetes & Endocrinology,BMJ,Journal of Clinical Endocrinology and Metabolism,BMC Medicine, International Journal of Epidemiology,PLOS One,BMC Complementary and Alternative Medicine,Journal of Epidemiology and Community Health,Journal of Clinical Endocrinology and Metabolism,Neuroepidemiology,Psychiatry Research,BMC Cardiovascular Disorders,Statistics in Medicine,Journal of Epidemiology, Scientific Report,Sleep Research等国际医学期刊。
2015年起担任香港大学荣誉助理教授,博士生联合导师

主要承担或参与的课题

香港大学项目:Progression of carotid intima-media thickness and related cardiovascular outcomes in older Chinese people (项目编号201309176086);港币5.2(万元);起止时间:04/2014-12/2014(主持)
香港医疗卫生研究基金项目
:Do common liver virus infections (HAV, HBV and HCV) contribute to high diabetes risk in China?(项目编号12133631)港币70.1(万元);起止时间:04/2015-03/2016(主持 )
香港大学项目:Establishment of cardiovascular risk prediction score in middle-age to older Chinese people (项目编号201510159006)港币15(万元);起止时间:01/2016-12/2016(主持)
香港医疗卫生研究基金项目:A prospective study of Southern Chinese dietary pattern, foods and nutrients with cardiovascular disease mortality(项目编号13143241);港币53(万元);起止时间:04/2016-03/2017(主持)
广州市科信局对外合作项目
:广州生物库队列纵向随访及建立亚队列研究与维护(项目编号2012J5100041);300(万元);起止时间:01/2012-12/2014(参与)
广东省自然科学基金项目:酒精敏感、饮酒对心血管危险因素影响纵向研究(项目编号2015A030313891);10(万元);起止时间08/2015-08/2018(参与)

近期发表的主要文章

Research articles
1. Xu, L., Jiang, C. Q., Lam, T. H., Zhang, W. S., Zhu, F., Jin, Y. L., Thomas, G.N., Cheng, K. K. & Schooling, C.M. (2016). Mendelian randomization estimates of alanine aminotransferase with cardiovascular disease: Guangzhou Biobank Cohort Study. Human molecular genetics. Accepted on 22 December 2016. (DOI. 10.1093/hmg/ddw396).
2. Xu L, Jiang CQ, Schooling CM, Zhang WS, Cheng KK, Lam TH. Liver enzymes as mediators of association between obesity and diabetes: the Guangzhou Biobank Cohort Study. Annals of epidemiology 2016. Accepted on 20 November 2016. (DOI. 10.1016/j.annepidem.2016.11.002).
3. Yang S, Xu L (Joint 1st author), He Y, Jiang C, Jin Y, Cheng KK, Zhang W and Lam TH. Childhood secondhand smoke exposure and pregnancy loss in never smokers: the Guangzhou Biobank Cohort Study. Tob Control. 2016. Accepted on 23 December 2016. (DOI. 10.1136/tobaccocontrol-2016-053239).
4. Xu, L., Lam, T. H., Jiang, C. Q., Zhang, W. S., Jin, Y. L., Zhu, T., Thomas, G.N., Cheng, K. K. (2016). Changes in adiposity in an older Chinese population in rapid economic transition. Obesity, 24(10), 2217-2223. 
5. Xu L, Jiang CQ, Cheng KK, Au Yeung SL, Zhang WS, Lam TH and Schooling CM. (2015) Alcohol Use and Gamma-Glutamyltransferase Using a Mendelian Randomization Design in the Guangzhou Biobank Cohort Study. PloS one 10, e0137790.
6. Xu L, Jiang CQ, Schooling CM, Zhang WS, Cheng KK, Lam TH. Liver enzymes and incident diabetes in China: a prospective analysis of 10,764 participants in the Guangzhou Biobank Cohort Study. JECH. 2015;69(11):1040-1044.
7. Xu L, Jiang CQ, Lam TH, Zhang WS, Cherny SS, Thomas GN, Cheng KK. Sleep duration and memory in the elderly chinese: Longitudinal analysis of the Guangzhou Biobank Cohort Study. SLEEP. 2014;37:1737-1744
8. Xu L, Freeman G, Cowling BJ, Schooling CM. Testosterone therapy and cardiovascular events among men: a systematic review and meta-analysis of placebo-controlled randomized trials. BMC MEDICINE. 2013;11:108.
9. Xu L, Schooling CM, Chan WM, Lee SY, Leung GM, Lam TH. Smoking and hemorrhagic stroke mortality in a prospective cohort study of older Chinese. STROKE. Aug 2013;44(8):2144-2149.
10. Xu L, Jiang CQ, Schooling CM, Zhang WS, Cheng KK, Lam TH. Prediction of 4-year incident diabetes  in older Chinese: Recalibration of the Framingham diabetes score on guangzhou biobank cohort study. PREVENTIVE MEDICINE. 2014;69C:63-68
11. Xu L, Yeung SL, Kavikondala S, et al. Estradiol concentrations in young healthy US versus Chinese men. AMERICAN JOURNAL OF HUMAN BIOLOGY: THE OFFICIAL JOURNAL OF HUMAN BIOLOGY COUNCIL 2014;26(4),565-569.
12. Xu L, Au Yeung SL, Kavikondala S, Leung GM, Schooling CM. Testosterone concentrations in young healthy us versus Chinese men. AMERICAN JOURNAL OF HUMAN BIOLOGY: THE OFFICIAL JOURNAL OF THE HUMAN BIOLOGY COUNCIL. 2014;26(1):99-102.
13. Xu L, Chan WM, Hui YF, Lam TH. Association between HbA1c and cardiovascular disease mortality in older Hong Kong Chinese with diabetes. DIABETIC MEDICINE 2012;29(3):393-8.
14. Xu L, Jiang CQ, Lam TH, Bao B, Cheng KK, Thomas GN. Plasminogen activator inhibitor-1 and HbA1c defined prediabetes: the Guangzhou Biobank Cohort Study-CVD. CLINICAL ENDOCRINOLOGY (Oxf) 2011;74(4):528-31.
15. Xu L, Jiang CQ, Lam TH, Thomas GN, Zhang WS, Cheng KK. Passive smoking and aortic arch calcification in older Chinese never smokers: the Guangzhou Biobank Cohort Study. INTTERNATIONAL JOURNAL OF CARDIOLOGY 2011;148(2):189-93.
16. Xu L, Jiang CQ, Lam TH, Yue XJ, Lin JM, Cheng KK, et al. Arterial stiffness and left-ventricular diastolic dysfunction: Guangzhou Biobank Cohort Study-CVD. JOURNAL OF HUMAN HYPERTENSION 2011;25(3):152-8.
17. Xu L, Jiang CQ, Lam TH, Zhang WS, Thomas GN, Cheng KK. Dose-response relation between physical activity and cognitive function: guangzhou biobank cohort study. ANNALS OF EPIDEMIOLOGY 2011;21(11):857-63.
18. Xu L, Jiang CQ, Lam TH, Cheng KK, Yue XJ, Lin JM, et al. Impact of impaired fasting glucose and impaired glucose tolerance on arterial stiffness in an older Chinese population: the Guangzhou Biobank Cohort Study-CVD. METABOLISM 2010;59(3):367-72.
19. Xu L, Jiang CQ, Lam TH, Lin JM, Yue XJ, Cheng KK, et al. The metabolic syndrome is associated with subclinical atherosclerosis independent of insulin resistance: the Guangzhou Biobank Cohort Study-CVD. CLINICAL ENDOCRINOLOGY (Oxf) 2010;73(2):181-8.
20. Xu L, Jiang CQ, Lam TH, Liu B, Jin YL, Zhu T, et al. Short or long sleep duration is associated with memory impairment in older Chinese: the Guangzhou Biobank Cohort Study. SLEEP 2011;34(5):575-80.
21. Xu L, Jiang CQ, Lam TH, Thomas GN, Zhang WS, Cheng KK. Aortic arch calcification and vascular disease: the Guangzhou Biobank Cohort Study. CARDIOLOGY 2010;117(4):260-4.
22. Xu L, Jiang CQ, Lam TH, Yue XJ, Cheng KK, Liu B, et al. Brachial-ankle pulse wave velocity and cardiovascular risk factors in the non-diabetic and newly diagnosed diabetic Chinese: Guangzhou Biobank Cohort Study-CVD. DIABETES METABOLISM RESEARCH & REVIEW 2010;26(2):133-9.
23. Lam TH, Xu L, (joint first author) Schooling CM, Chan WM, Lee SY, Leung GM. Smoking and mortality in a prospective cohort study of older chinese in Hong Kong. ADDICTION. 2015;110(3):502-510.
24. Zhang WS, Xu L (join first author), Schooling CM, et al. Effect of alcohol and aldehyde dehydrogenase gene polymorphisms on alcohol-associated hypertension: the Guangzhou Biobank Cohort Study. HYPERTENSION RESEARCH. Aug 2013;36(8):741-746.
25. Zhao JV, Xu L, Lin SL and Schooling CM. Spironolactone and glucose metabolism, a systematic review and meta-analysis of randomized controlled trials. Journal of the American Society of Hypertension : JASH. 2016;10:671-82.
26. Sun WJ, Xu L, Chan WM, Lam TH, Schooling CM. Are Depressive Symptoms Associated With Cardiovascular Mortality Among Older Chinese: A Cohort Study of 64,000 People in Hong Kong? THE AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY. Aug 14 2012.
27. Sun WJ, Xu L, Chan WM, Lam TH, Schooling CM. Depressive symptoms and suicide in 56,000 older Chinese: a Hong Kong cohort study. SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY. Apr 2012;47(4):505-514.
28. Jiang CQ, Xu L, Lam TH, Lin JM, Cheng KK, Thomas GN. Smoking cessation and carotid atherosclerosis: the Guangzhou Biobank Cohort Study--CVD. JECH. Nov 2010;64(11):1004-1009.
29. Jiang CQ, Xu L, Lam TH, Thomas GN, Zhang WS, Cheng KK, Schooling CM. Alcohol consumption and aortic arch calcification in an older chinese sample: The guangzhou biobank cohort study. INTERNATIONAL JOURNAL OF CARDIOLOGY. 2013;164:349-354
30. Wang Y, Li YY, Nie YQ, Zhou YJ, Cao CY, Xu L. Association between metabolic syndrome and the development of non-alcoholic fatty liver disease. EXPERIMENTAL AND THERAPEUTIC MEDICINE. Jul 2013;6(1):77-84.
31. Pan J, Xu L, Cai SX, Jiang CQ, Cheng KK, Zhao HJ, Zhang WS, Jin YL, Lin JM, Thomas GN, Lam TH: The association of pulmonary function with carotid atherosclerosis in older Chinese: Guangzhou Biobank Cohort Study-CVD Subcohort. Atherosclerosis 2015;243:469-476
32. Jiang CQ, Chan YH, Xu L (corresponding author), Jin YL, Zhu T, Zhang WS, Cheng KK, Lam TH. (2016) Smoking and serum vitamin D in older Chinese people: cross-sectional analysis based on the Guangzhou Biobank Cohort Study. BMJ Open (Accepted in 3 May 2016)
33. Zhao, J., Jiang, C., Lam, T.H., Liu, B., Cheng, K.K., Xu, L., Long, M.J., Zhang, W., Leung, G.M. & Schooling, C.M. (2014) Genetically predicted testosterone and electrocardiographic QT interval duration in Chinese: a Mendelian randomization analysis in the Guangzhou Biobank Cohort Study. Int J Epidemiol.
34. Zhao, J., Jiang, C., Lam, T.H., Liu, B., Cheng, K.K., Xu, L., Au Yeung, S.L., Zhang, W., Leung, G.M. & Schooling, C.M. (2015) Genetically Predicted Testosterone and Systemic Inflammation in Men: A Separate-Sample Mendelian Randomization Analysis in Older Chinese Men. PLoS One 10, e0126442.
35. Lin QH, Jiang CQ, Lam TH, Xu L, Jin YL, Cheng KK. Past occupational dust exposure, depressive symptoms and anxiety in retired chinese factory workers: The guangzhou biobank cohort study. JOURNAL OF OCCUPATIONAL HEALTH. 2014 [EPub Date: 2014/09/13]
36. Jagielski AC, Jiang CQ, Xu L, Taheri S, Zhang WS, Cheng KK, Lam TH, Thomas GN. Glycaemia is associated with cognitive impairment in older adults: The guangzhou biobank cohort study. AGE AND AGEING. 2014 [EPub Date: 2014/07/10]
37. Zhao J, Jiang C, Lam TH, Liu B, Cheng KK, Xu L, Au Yeung SL, Zhang W, Leung GM, Schooling CM. Genetically predicted testosterone and cardiovascular risk factors in men: A mendelian randomization analysis in the guangzhou biobank cohort study. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY. 2014;43(1):140-148
38. Gui H, Jiang CQ, Cherny SS, Sham PC, Xu L, Liu B, Jin YL, Zhu T, Zhang WS, Thomas GN, Cheng KK, Lam TH. Influence of alzheimer's disease genes on cognitive decline: The guangzhou biobank cohort study. NEUROBIOLOGY OF AGING. 2014;35:2422 e2423-2428 
39. Jin YL, Zhu T, Xu L, Zhang WS, Liu B, Jiang CQ, Yu H, Huang LM, Cheng KK, Thomas GN, Lam TH. Uric acid levels, even in the normal range, are associated with increased cardiovascular risk: the Guangzhou Biobank Cohort Study. INTERNATIONAL JOURNAL OF CARDIOLOGY. Oct 3 2013;168(3):2238-2241.
40. Shen C, Schooling CM, Chan WM, Xu L, Lee SY, Lam TH. Alcohol intake and death from cancer in a prospective Chinese elderly cohort study in Hong Kong. JECH. Oct 2013;67(10):813-820.
41. Long MJ, Jiang CQ, Lam TH, Xu L, Zhang WS, Lin JM, Ou JP and Cheng KK: Atrial fibrillation and obesity among older Chinese: the Guangzhou Biobank Cohort Study. INTERNATIONAL JOURNAL OF CARDIOLOGY 148:48-52, 2011
42. Jin YL, Liu B, Jiang CQ, Xu L, Guo LH, Lam TH, Lin JM, Zhang WS, Cheng KK and Gn T: [Study on the association between gene polymorphism of ENPP1 and left ventricular hypertrophy: a Guangzhou Biobank Cohort Study-CVD]. CHINESE JOURNAL OF EPIDEMIOLOGY 31:742-6, 2010 (in Chinese)
43. Tang CS, Zhang H, Cheung CY, Xu M, Ho JC, Zhou W, Cherny SS, Zhang Y, Holmen O, Au KW, Yu H, Xu L, Jia J, Porsch RM, Sun L, Xu W, Zheng H, Wong LY, Mu Y, Dou J, Fong CH, Wang S, Hong X, Dong L, Liao Y, Wang J, Lam LS, Su X, Yan H, Yang ML, Chen J, Siu CW, Xie G, Woo YC, Wu Y, Tan KC, Hveem K, Cheung BM, Zollner S, Xu A, Eugene Chen Y, Jiang CQ, Zhang Y, Lam TH, Ganesh SK, Huo Y, Sham PC, Lam KS, Willer CJ, Tse HF, Gao W: Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese. Nature communications 2015;6:10206
44. Lin JH, Jiang CQ, Ho SY, Zhang WS, Mai ZM, Xu L, Lo CM, Lam TH: Smoking and nasopharyngeal carcinoma mortality: a cohort study of 101,823 adults in Guangzhou, China. BMC cancer 2015;15:906
45. Tang CS, Zhang H, Cheung CY, Xu M, Ho JC, Zhou W, Cherny SS, Zhang Y, Holmen O, Au KW, Yu H, Xu L, Jia J, Porsch RM, Sun L, Xu W, Zheng H, Wong LY, Mu Y, Dou J, Fong CH, Wang S, Hong X, Dong L, Liao Y, Wang J, Lam LS, Su X, Yan H, Yang ML, Chen J, Siu CW, Xie G, Woo YC, Wu Y, Tan KC, Hveem K, Cheung BM, Zöllner S, Xu A, Eugene Chen Y, Jiang CQ, Zhang Y, Lam TH, Ganesh SK, Huo Y, Sham PC, Lam KS, Willer CJ, Tse HF, Gao W. Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese. Nat Commun. 2015 Dec 22;6:10206. doi: 10.1038/ncomms10206. PubMed PMID: 26690388; PubMed Central PMCID: PMC4703860.

 Letters
1. Lam TH and Xu L. Commentary: Fundamental limitations of meta-analysis of cohort studies, epidemiological challenges and the stage of obesity epidemic. Int J Epidemiol. 2016. (DOI. 10.1093/ije/dyw309) 
2. Xu L, Au Yeung SL and Schooling CM. Does the optimal BMI really vary by age and sex? International journal of epidemiology. 2016;45:285-6.
3. Xu L, Schooling CM. Differential risks in men and women for first and recurrent venous thrombosis: the role of genes and environment: comment. Journal of thrombosis and haemostasis : JTH. 2015; 13(5): 884-6.
4. Schooling CM, Xu L, Zhao J, Au Yeung SL. Norms hide causes-the example of testosterone. Int J Epidemiol. 2014; 43(6): 1987-8.
5. Schooling CM, Leung GM, Xu L. Promotion of "low t" and the role of testosterone clinical trials. JAMA internal medicine. 2014; 174(2): 305-6.
 

研究生培养情况
自2012年以来平均每年培养3-4名硕士研究生,自2015年以来担任博士生联合导师

招生专业
慢性病流行病学
 
获奖情况

2008 获贺达理教授奖(Professor Anthony Hedley Prize for Master of Public Health), 香港大学(年级总分第一名,优秀毕业论文奖)
2011获龍榮軾教授及朱淑濂女士研究生奖学金(YS and Christabel Lung Postgraduate Scholarship), 香港大学
2011年参与项目《广州生物库中老年队列的建立与常见慢性重大疾病的相关因素研究》,研究团队获中华预防医学会科学进步奖二等奖
2012再次获龍榮軾教授及朱淑濂女士研究生奖学金(YS and Christabel Lung Postgraduate Scholarship), 香港大学
2014年参与项目《广州生物库中老年队列的建立与常见慢性重大疾病的相关因素研究》,研究团队获广东省科学技术进步奖二等奖
2015年获香港大学/美国中华医学基金会(University of Hong Kong/China Medical Board)联合基金资助