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赵立娜 教授

职  称: 教授 (博士生导师)\

所属部门: 营养学系

电子邮件:  zhaoln5@mail.sysu.edu.cn; linazhao1010@163.com 

联系电话:020-87330446

研究方向(主要研究领域)


主要研究领域: 营养与慢性疾病   
主要研究方向: 膳食因素对血管内皮调节脂肪酸和激素转运等功能的影响及其在肥胖、糖尿病和动脉粥样硬化等疾病发生发展中的机制,并进一步开展人群营养验证和干预研究。


学术简历


2016.12- 至今   中山大学公共卫生学院  “百人计划”引进  教授/博士生导师
2015.7-2016.6   美国耶鲁大学  心血管中心   副研究员
2010.8-2015.6   美国弗吉尼亚大学 内分泌代谢系   博士后研究员
2005.9-2010.6   华中科技大学同济医学院公共卫生学院 营养与食品卫生专业 博士
2000.9-2005.6   华中科技大学同济医学院  预防医学    学士

社会兼职

杂志编委: Journal of Nutrition and Diabetes
杂志审稿人 : Apoptosis,Biological Trace Element Research,BMC Public Health,Diabetes & Metabolism,Microvascular Research,Life Science
中国营养学会会员

主要承担或参与的课题

2018-2020   国家自然科学基金青年科学基金项目81703212 (主持)
2016-2021   中山大学 “百人计划” 项目资助 (主持)
2010-2014   Insulin action in human cardiac and skeletal muscle microvasculature  美国国立卫生研究1R01HL094722主要参与者
2008-2010    碘过量致脂代谢紊乱的基础研究   国家自然科学基金面上项目30771806主要参与者
2004-2006    酒精对胰岛素敏感性的影响及与 2 型糖尿病的关系  国家自然科学基金面上项目30300282 主要参与者


近期发表的主要文章

1. Hwangbo C, Wu J, Papangeli I, Adachi T, Sharma B, Park S, Zhao L, Ju H, Go GW, Cui G, Inayathullah M, Job JK, Rajadas J, Kwei SL, Li MO, Morrison AR, Quertermous T, Mani A, Red-Horse K, Chun HJ.  Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin's glucose-lowering effects. Sci Transl Med. 2017; 13;9(407).
2. Ceneri N*, Zhao L*, Young BD, Healy A, Coskun S, Vasavada H, Yarovinsky TO, Ike K, Pardi R, Qin L, Qin L, Tellides G, Hirschi K, Meadows J, Soufer R, Chun HJ, Sadeghi MM, Bender JR, Morrison AR  Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1β Production.. Arterioscler Thromb Vasc Biol. 2017; 37(2):328-340. (* co-first author)
3. Zhao L, Fu Z, Wu J, Aylor KW, Barrett EJ, Cao W, Liu Z. Globular adiponectin ameliorates metabolic insulin resistance via AMPK-mediated restoration of microvascular insulin responses. J Physiol. 2015; 593(17):4067-79.
4. Zhao L, Fu Z, Wu J, Aylor KW, Barrett EJ, Cao W, Liu Z. Inflammation-induced microvascular insulin resistance is an early event in diet-induced obesity.  Clin Sci (Lond). 2015; 129(12):1025-36.
5. Zhao L, Liu Z. Adiponectin and insulin crosstalk: the microvasculature connection. Trends Cardiovasc Med. 2014; 24(8):319-324. 
6. Fu Z, Zhao L, Aylor KW, Carey RM, Barrett EJ, Liu Z. Angiotensin-(1-7) recruits muscle microvasculature and enhances insulin’s metabolic action via Mas receptor.  Hypertension. 2014; 63(6):1219-27.
7. Fu Z, Zhao L, Chai W, Dong Z, Cao W, Liu Z. Ranolazine recruits muscle microvasculature and enhances insulin action in rats. J Physiol. 2013; 591(20):5235-49.
8. Zhao L,  Chai W, Fu Z, Dong Z, Aylor KW, Barrett EJ, Cao W, Liu Z. Globular adiponectin enhances muscle insulin action via microvascular recruitment and increased insulin delivery. Circ Res. 2013; 112(9):1263-71.
9. Wang N, Chai W, Zhao L, Tao L, Cao W, Liu Z. Losartan increases muscle insulin delivery and rescues insulin's metabolic action during lipid infusion via microvascular recruitment. Am J Physiol Endocrinol Metab. 2013; 304(5):538-45.
10. Dong Z, Chai W, Wang W, Zhao L, Fu Z, Cao W, Liu Z. Protein kinase A mediates glucagon-like peptide 1-induced nitric oxide production and muscle microvascular recruitment. Am J Physiol Endocrinol Metab. 2013; 304(2):222-8.
11. Zhao LN, Xu J, Peng XL, Tian LY, Hao LP, Yang XF, Ying CJ, Sun XF.Dose and time-dependent hypercholesterolemic effects of iodine excess via TRβ1mediated down regulation of hepatic LDLr gene expression. Eur J Nutr. 2010; 49(5):257-65
12. Zhao LN, Hao LP, Yang XF, Ying CJ, Yu D, Sun XF. The diabetogenic effects of excessive ethanol: reducing beta-cell mass, decreasing phosphatidylinositol 3-kinase activity and GLUT-4 expression in rats. Br J Nutr. 2009; 101(10):1467-73. 

会议报告
1. Zhao L, Yang X, Xu J, Sun X. iodine intake and health: the more, the better?  Oral Presentation at the 16th World Congress on Nutrition and Food Chemistry, Zurich, Swissland, 2017.
2. L Zhao, AL Healy, N Ceneri, G Bailey, J Meadows, M Sadeghi, .AR Morrison.Statins Modulate Rac-dependent IL-1 beta Expression to Influence Calcium Composition. Poster Presentation at Arteriosclerosis, Thrombosis, and Vascular Biology 36 (Suppl 1), A650-A650, 2016.
3. Zhao L, Ceneri N, Young B, Coskun S, Vasavada H, Yarovinsky T, Ike K, Hirschi K, Sadeghi M, Bender J, and Morrison A. Macrophage Racs Modulate IL-1β dependent calcification in Atherosclerotic Plaque.  Poster Presentation at the Fifteenth Annual Scientific Meeting of Yale Vascular Biology & Therapeutics Program, New Haven, United States, 2015.
4. Zhao L, Fu Z, Wu J, Barrett EJ, Liu Z. Salicylate ameliorates high-fat diet induced Microvascular and metabolic insulin resistance. Poster Presentation at the American Diabetes Association's 74th Scientific Sessions, San Francisco, United States. 2014.  
5. Zhao L, Fu Z, Chai W, Barrett EJ, Liu Z. Microvascular insulin resistance precedes metabolic insulin resistance during high fat feeding. Oral Presentation at the American Diabetes Association's 73rd Scientific Sessions, Chicago, United States.2013.
6. Zhao L, Fu Z, Dong Z, Barrett EJ, Liu Z. Globular adiponectin ameliorates high fat diet-induced microvascular and metabolic insulin resistance and improves arterial endothelial function. Poster Presentation at the American Diabetes Association's 73rd Scientific Sessions, Chicago, United States.2013.
7. Zhao L, Chai W, Fu Z, Dong Z, Barrett EJ, Liu Z. Globular adiponectin induced microvascular recruitment contributes to its insulin-sensitizing effect. Poster Presentation at the American Diabetes Association's 72nd Scientific Sessions, Philadelphia , United States.2012
8. 赵立娜, 曲巍,郝丽萍, 刘烈刚,孙秀发. 长期酒精摄入对原代培养大鼠骨骼肌细胞胰岛素信号的影响.  大会报告,湖北省营养学会武汉营养学会第十二次学术会议,湖北武汉市, 2009.
9. 赵立娜,徐健,彭晓琳,田利钺,郝丽萍,杨雪峰,应晨江,孙秀发.长期过量碘摄入对小鼠脂蛋白代谢影响. 壁报交流,全国营养学会第十次微量元素会议. 湖北恩施市, 2009 

招生专业


预防医学 营养与食品卫生学

获奖情况

2016   中山大学“百人计划”引进
2014   弗吉尼亚大学新视野会议奖
2014   Life Science优秀审稿人   
2009 华中科技大学优秀研究生论文   
2005 华中科技大学优秀毕业生