【职称】高级工程师
  【学位/学历】博士研究生
   医学营养学博士
【学习经历】英国阿伯丁大学医学院
   医学营养学 （基础医学）/博士
【工作经历】内蒙古蒙牛乳业（集团）股份有限公司
  张旭光博士曾先后在英国上市公司Provexis Plc（药品、功能食品研发型上市公司）任职高级科学家；英国上市公司Science in Sport Plc（运动营养英国排名前五）任职高级科学家及新产品研发负责人（高管）；新西兰恒天然乳业集团研发总部任职高级科学家、营养学家；汤臣倍健股份有限公司任职营养健康研究院执行院长，集团科技中心总经理；中国科学院上海营养与健康研究所兼职研究员(编制内)；内蒙古蒙牛乳业（集团）股份有限公司集团副总裁（高管），营养健康研究院负责人。长期致力于营养健康研究、临床与功能研究，合成生物学、微生态技术研究、心血管健康、代谢健康、肠道健康、婴幼儿营养、运动营养及老年营养等相关功能性原料、食品、药品的创新与研发。在英国阿伯丁大学罗威特营养与健康研究所任研究员期间，从事系统性炎症标志物及干预、乳清蛋白多肽功能（研究员期间）等基础医学、临床医学相关的科研工作。2010年张旭光博士带领英国科研团队申报并开创了欧盟批准的第一个营养健康新功能概念及声称：“维持血小板正常聚集、维持正常血流健康”(欧洲食品安全管理委员会，EFSA 新法案13.5)。
【研究方向及兴趣】
营养健康科学、临床与功能研究、合成生物学、微生态技术研究、生物信息分析
张旭光博士，是营养健康科学、临床与功能研究、合成生物学、微生态技术研究、生物信息分析等多领域专家。现任蒙牛集团副总裁（高管）、营养科学研究院负责人。曾在英国、新西兰院校及上市公司任职，长期致力于合成生物领域研究、微生态技术研究、医学科研（心血管健康、代谢健康、肠道健康、婴幼儿营养、运动营养及老年营养等）相关功能性原料研究开发、注册制保健食品、药品的创新与研发和管理工作，拥有丰富的国内外研究和工作经历。
【论文代表作（近五年）】
[1]Shanshan Hu, Fang Tian, Shiqi Yi, Qihang Liu, Shilin Liu, Yanrong Zhao, Xuguang Zhang, Yan Li. Influence of whey protein types on the bioaccessibility of β-carotene in different formulations: Emulsions vs microcapsules. Food Bioscience, 2025
[2]Chen H, Xiong R, Cheng J, Ye J, Qiu Y, Huang S, Li M, Liu Z, Pang J, Zhang X, Guo S, Li H, Zhu H. Effects and Mechanisms of Polyunsaturated Fatty Acids on Age-Related Musculoskeletal Diseases: Sarcopenia, Osteoporosis, and Osteoarthritis-A Narrative Review. Nutrients. 2024 Sep 
[3]Ye J, Cheng J, Xiong R, Chen H, Huang S, Li H, Pang J, Zhang X, Zhu H. Effects and Mechanisms of Lutein on Aging and Age-Related Diseases. Antioxidants (Basel). 2024 Sep 
[4]Yi Zhang, Xuemei Wang, Jun Lin, Jia Liu, Kai Wang, Qixing Nie, Chuan Ye, Lulu Sun, Yanpeng Ma, Ruize Qu, Yuejian Mao, Xuguang Zhang, Hua Lu, Pengyan Xia, Dongyu Zhao, Guang Wang, Zhipeng Zhang, Wei Fu, Changtao Jiang, Yanli Pang: A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH. Cell Metabolism, 2024.
[5]Yanpu Wu, Xinyan Zhang, Liang Sun, Qingqing Wu, Xiaoping Liu, Yueyi Deng, Zhenzhen Lu, Zhongxia Li, Chaoming Deng, Ruikun He, Luyun Zhang, Rong Zeng, Xuguang Zhang, Luonan Chen, Xu Lin, Two-dimensional Health State Map to define metabolic health using separated static and dynamic homeostasis features: a proof-of-concept study, National Science Review.2024 Jan
[6]Xinyu Cui, Yu Dong, Qiang Zhan, Yixin Huang, Qianshu Zhu, Zihao Zhang, Guang Yang, Liping Wang, Shijun Shen, Jia Zhao, Zhiyi Lin, Jiatong Sun, Zhongqu Su, Yihan Xiao, Chuyu Zhang, Yuwei Liang, Lu Shen, Lichen Ji, Xuguang Zhang, Jiqing Yin, Hong Wang, Zhiyang Chen, Zhenyu Ju, Cizhong Jiang, Shaorong Gao: Altered 3D genome reorganization mediates precocious myeloid differentiation of aged hematopoietic stem cells in inflammation. Sci. China Life Sci. (2024).
[7]Birong Jiang, Wei Zhang, Xuguang Zhang, Yu Sun: Targeting senescent cells to reshape the tumor microenvironment and improve anticancer efficacy. Semin Cancer Biol, 2024 Jun.
[8]Wei Chen, Xi Zhao, Zhenghua Huang, Shihui Luo, Xuguang Zhang, Wei Sun, Tao Lan, Ruikun He: Determination of Flavonolignan Compositional Ratios in Silybum marianum (Milk Thistle) Extracts Using High-Performance Liquid Chromatography. Molecules, 2024 Jun 21.
[9]Jialin Xia, Hong Chen, Xiaoxiao Wang, Weixuan Chen, Jun Lin, Feng Xu, Qixing Nie, Chuan Ye, Bitao Zhong, Min Zhao, Chuyu Yun, Guangyi Zeng, Yuejian Mao, Yongping Wen, Xuguang Zhang, Sen Yan, Xuemei Wang, Lulu Sun, Feng Liu, Chao Zhong, Pengyan Xia, Changtao Jiang, Huiying Rao, Yanli Pang: Sphingosine d18:1 promotes nonalcoholic steatohepatitis by inhibiting macrophage HIF-2α. Nat Commun, 2024 Jun 4.
[10]Yuexing Liu, Yao Luo, Xin Lu, Hao Gao, Ruikun He, Xin Zhang, Xuguang Zhang, Yixue Li: Genotypic-phenotypic landscape computation based on first principle and deep learning. Brief Bioinform, 2024 Mar 27.
[11]Weiwei Yi, Jinhua Zhang, Yingxin Huang, Qiang Zhan, Mi Zou, Xiang Cheng, Xuguang Zhang, Zhinan Yin, Si Tao, Hui Cheng, Fudi Wang, Jun Guo, Zhenyu Ju, Zhiyang Chen: Ferritin-mediated mitochondrial iron homeostasis is essential for the survival of hematopoietic stem cells and leukemic stem cells. Leukemia, 2024 May.
[12]Yushuang Wang, Binqi Rui, Xiaolei Ze, Yujia Liu, Da Yu, Yinhui Liu, Zhi Li, Yu Xi, Xixi Ning, Zengjie Lei, Jieli Yuan, Liang Li, Xuguang Zhang, Wenzhe Li, Yanjie Deng, Jingyu Yan, Ming Li :Sialic acid-based probiotic intervention in lactating mothers improves the neonatal gut microbiota and immune responses by regulating sialylated milk oligosaccharide synthesis via the gut-breast axis. Gut Microbes, 2024 Jan-Dec.
[13]Yu Li , Zhong-Hao Zhang , Shao-Ling Huang , Zhong-Bao Yue , Xue-Song Yin , Zi-Qi Feng , Xu-Guang Zhang , Guo-Li Song：Whey protein powder with milk fat globule membrane attenuates Alzheimer's disease pathology in 3×Tg-AD mice by modulating neuroinflammation through the peroxisome proliferator-activated receptor γ signaling pathway. J Dairy Sci, 2023 Aug.
[14]Wei Sun, Jian He, Yihan Zhang, Ruikun He, Xuguang Zhang: Comprehensive functional evaluation of a novel collagen for the skin protection in human fibroblasts and keratinocytes. Biosci Biotechnol Biochem, 2023 Jun 23.
[15]Teresa Grohmann, Alan W Walker, Wendy R Russell, Nigel Hoggard, Xuguang Zhang, Graham Horgan, Baukje de Roos: A grape seed and bilberry extract reduces blood pressure in individuals at risk of developing type 2 diabetes: the PRECISE study, a double-blind placebo-controlled cross-over intervention study. Front Nutr, 2023 Jun 7.
[16]Xiaoqin Li, Shan Hu, Jiawei Yin, Xiaobo Peng, Lei King, Linyan Li, Zihui Xu, Li Zhou, Zhao Peng, Xiaolei Ze, Xuguang Zhang, Qiangchuan Hou, Zhilei Shan, Liegang Liu: Effect of synbiotic supplementation on immune parameters and gut microbiota in healthy adults: a double-blind randomized controlled trial. Gut Microbes, 2023.
[17]Hao Lai, Yunfeng Li, Yafang He, Fangyao Chen, Baibing Mi, Junqi Li, Jiawen Xie, Guoqing Ma, Jinzhao Yang, Kun Xu, Xia Liao, Yan Yin, Junrong Liang, Liyun Kong, Xinyan Wang, Zhongxia Li, Yuan Shen, Shaonong Dang, Lei Zhang, Qian Wu, Lingxia Zeng, Lin Shi, Xuguang Zhang, Tian Tian, Xin Liu: Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial. Gut Microbes, 2023.
[18]Lu Xiaoting, Wang Yina, Mo Qiwan, Huang Bixia, Wang Yufang, Huang Zihui, Luo Yan, Maierhaba Wusiman, He Tongtong, Li Shuyi, Huang Rongzhu, Yang Mengtao, Liu Xiaozhan, Liu Zhaoyan, Chen Si, Fang Aiping, Zhang Xuguang, Zhu Huilian: Effects of low-dose B vitamins plus betaine supplementation on lowering homocysteine concentrations among Chinese adults with hyperhomocysteinemia: a randomized, double-blind, controlled preliminary clinical trial. Eur J Nutr, 2023.
[19]Yang Fan, Zhang Xuguang, Hu Feifei, Yu Ye, Luo Lei, Deng Xuan, Zhao Yuzheng, Pan Bo, Zheng Jinping, Qiu Yugang, Guo Jun, Xiao, Xie Xiaomei, Ju Zhenyu, Zhou Yong: Association between NAD(+) levels and anaemia among women in community-based study. J Cell Mol Med, 2022.
[20]Yang Fan, Deng Xuan, Yu Ye, Luo Lei, Chen Xianda, Zheng Jinping, Qiu Yugang, Xiao Feng, Xie Xiaomei, Zhao Yuzheng, Guo Jun, Hu Feiei, Zhang Xuguang, Ju Zhenyu, Zhou Yong: Association of Human Whole Blood NAD(+) Contents With Aging. Front Endocrinol (Lausanne), 2022.
[21]Sun Yujie, Wang Zhijun, Nie Chengzhipeng, Xue Lamei, Wang Yu, Liu Jinxin, Fan Mingcong, Zhang Duo, He Ruikun, Zhang Xuguang, Qian Haifeng, Billi K.C. Chow, Li Yan Wang Li: Hydroxysafflor yellow A triggered a fast-to-slow muscle fiber-type conversion via regulating FoxO1 in myocytes. Food Funct, 2022.
[22]Nie Chenzhipeng, Li Tingting, Fan Mingcong, Wang Yu, Sun Yujie, He Ruikun, Zhang Xuguang, Qian Haifeng, Ying Hao, Wang Li, Li Yan: Polyphenols in Highland barley tea inhibit the production of Advanced glycosylation end-products and alleviate the skeletal muscle damage. Mol Nutr Food Res, 2022.
[23]Liu Lu, Xiao Shunli, Wang Yilin, Wang Yufang, Liu Lei, Sun Zhengxiao, Zhang Qian, Yin Xiaojie, Liao Fulong, You Yun, Zhang Xuguang: Water-soluble tomato concentrate modulates shear-induced platelet aggregation and blood flow in vitro and in vivo. Mol Nutr Food Res, 2022.
[24]Liang Huijing, Ze Xiaolei, Wang Silu, Wang Yimei, Peng Chenrui, Cheng Ruyue, Jiang Fengling, Wu Simou, He Ruikun, He Fang, Zhang Xuguang, Shen Xi: Potential Health-Promoting Effects of Two Candidate Probiotics Isolated from Infant Feces Using an Immune-Based Screening Strategy. Nutrients, 2022.
[25]Li Zhongxia, Zhang Huibin, He Li, Hou Yaqin, Che Yingjuan, Liu Tian, Xiong Shaobai, Zhang Xuguang, Luo Shunjing, Liu Chengmei, Chen Tingting: Influence of structural features and feruloylation on fermentability and ability to modulate gut microbiota of arabinoxylan in in vitro fermentation. Front Microbiol, 2022.
[26]Huang Li, Lv Xia, Ze Xiaolei, Ma Zewei, Zhang Xuguang, He Ruikun, Fan Junting, Zhang Meilin, Sun Boran, Wang Fang, Liu Huan: Combined probiotics attenuate chronic unpredictable mild stress-induced depressive-like and anxiety-like behaviors in rats. Front Psychiatry, 2022.
[27]Fu Min, Liang Xiaoshan, Zhang Xuguang, Yang Mingzhe, Ye Qi, Qi Yuxuan, Liu Huan, Zhang Xumei: Astaxanthin delays brain aging in senescence-accelerated mouse prone 10: inducing autophagy as a potential mechanism. Nutr Neurosci, 2022.
[28]Chen Huilian, Zhang Shenghao, Wang Hui, He Ruikun, Zhang Xuguang, Qi Ruomei: Effect of fruitflow on platelet function: A randomized placebo-controlled clinical trial in middle-aged and elderly subjects. J Funct Foods, 2022.
[29]Yang Liu, Ye Qi, Zhang Xuguang, Li Ke, Liang Xiaoshan, Wang Meng, Shi Linran, Luo Suhui, Zhang Qiang, Zhang Xumei: Pyrroloquinoline quinone extends Caenorhabditis elegans' longevity through the insulin/IGF1 signaling pathway-mediated activation of autophagy. Food Funct, 2021.
[30]Xu Qixia, Fu Qiang, Li Zi, Liu Hanxin, Wang Ying, Lin Xu, He Ruikun, Zhang Xuguang, Ju Zhenyu, Campisi Judith, James L. Kirkland, Sun Yu: The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice. Nat Metab, 2021.
[31]Teresa Grohmann, Caroline Litts, Graham Horgan, Zhang Xuguang, Nigel Hoggard, Wendy Russell, Baukja de Roos: Efficacy of Bilberry and Grape Seed Extract Supplement Interventions to Improve Glucose and Cholesterol Metabolism and Blood Pressure in Different Populations-A Systematic Review of the Literature. Nutrients, 2021.
[32]Fu Min, Zhang Xumei, Zhang Xuguang, Yang Liu, Luo Suhui, Liu Huan: Autophagy Plays a Role in the Prolongation of the Life Span of Caenorhabditis elegans by Astaxanthin. Rejuvenation Res, 2021.
[33]Zhu Xudong, Shen Weiyan, Liu Zhu, Sheng Shihao, Xiong Wei, He Ruikun, Zhang Xuguang, Ma Likun, Ju Zhenyu: Effect of Metformin on Cardiac Metabolism and Longevity in Aged Female Mice. Front Cell Dev Biol, 2020.
[34]Yang Mingzhe, Zhang Xuguang, Ding Zhenkai, Wang Feijie, Wang Yufang, Jiao Changya, Chen Jiehua: Low skeletal muscle mass is associated with arterial stiffness in community-dwelling Chinese aged 45 years and older. BMC Public Health, 2020.
[35]Sun Shengwei, He Jian, Liu Meijuan, Li Kunping, Zhang Xuguang, Yin Guangling, Comparison of determination of phenolic compounds in the Baccharis dracunculifolia propolis and domestic propolis by Folin-phenol method and high performance liquid chromatography. Journal of Food Safety Quality, 2020.
[36]Liu Han, Zhang Xuguang, Xiao Jie, Song Mingyue, Cao Yong, Xiao Hang, Liu Xiaojuan: Astaxanthin attenuates d-galactose-induced brain aging in rats by ameliorating oxidative stress, mitochondrial dysfunction, and regulating metabolic markers. Food Funct, 2020.
[37]Lin Yun, Chen Jiehua, He Ruikun, Tang Bingxuan, Jiang Limiao, Zhang Xuguang: A fully validated high-throughput liquid chromatography tandem mass spectrometry method for automatic extraction and quantitative determination of endogenous nutritional biomarkers in dried blood spot samples. J Chromatogr A, 2020.
[38]Liang Huijing, Luo Zihao, Miao Zhonghua, Shen Xi, Li Ming, Zhang Xuguang, Chen Jiehua, Ze Xiaolei, Chen Qiwei, He Fang: Lactobacilli and bifidobacteria derived from infant intestines may activate macrophages and lead to different IL-10 secretion. Biosci Biotechnol Biochem, 2020.
[39]Zhang Qian, Zhang Xuguang, Liu Lei, Zhang Qiongling, Ding Shilan, Chen Ying, Wang Jinyu, Wang Lan, Liang Rixin, Liao Fulong: Effects of water-soluble tomato concentrate on platelet aggregation. World J Tradit Chin Med, 2019.
[40]Sun Shengwei, Liu Meijuan, He Jian, Li Kunping, Zhang Xuguang, Yin Guangling: Identification and Determination of Seven Phenolic Acids in Brazilian Green Propolis by UPLC-ESI-QTOF-MS and HPLC. Molecules, 2019.
[41]Feng Ruibing, Chen Jiehua, Liu Conghui, Xia Fangbo, Xiao Zeyu, Zhang Xuguang, Wan Jianbo: A combination of Pueraria lobata and Silybum marianum protects against alcoholic liver disease in mice. Phytomedicine, 2019.
[42]Chen Liangkai, Zhang Xuguang, Wang Qiang, Li Wanyi, Liu Liegang: Effect of Vaccinium myrtillus Extract Supplement on Advanced Glycation End-products: A Pilot Study. Curr Dev Nutr 2019.
【研究项目】
1. 合成生物领域：突破母乳低聚糖（HMO）技术
项目概述：带领蒙牛合成生物研究部与临床与功能研究部，在母乳低聚糖（HMO）新食品原料研发上取得重大突破。成功研发出中国本土自主的母乳低聚糖（HMO），并通过了国家卫生健康委员会的审批，成为首批获批企业中唯一的中国本土企业，且通过了国家农业部认证。
2. 微生态技术与益生菌领域：突破自主菌株研发技术
2.1 自主菌株LPB27的研发与商业转化
项目概述：在汤臣倍健任职期间，带领团队历时7年，成功实现中国本土优质益生菌株LPB27的研发和商业化应用，推动了中国益生菌产业的发展。
2.2 蒙牛自主益生菌研发平台建设
项目概述：带领团队建设国际领先的微生态研发平台，完成10多个益生菌研发项目，并推动蒙牛自主菌株的研发与应用研究。
3. 开创新功能注册保健品：国内外首次申报新功能
3.1 欧盟批准的第一个营养健康新功能概念及声称
项目概述：2010年，在Provexis Plc（英国）工作期间，带领科研团队申报并成功开创了欧盟批准的第一个营养健康新功能概念及声称，涉及“维持血小板正常聚集、维持正常血流健康”，为欧洲保健食品行业做出了贡献。
3.2 国内首个新功能注册保健食品开发
项目概述：历时8年，带领团队成功申报“有助于维持正常血小板聚集功能，有益于血流健康”的保健食品新功能，成为行业内首家递交新功能申报及产品注册申请的企业。
4. 精准营养技术：解决精准营养领域卡脖子技术
4.1 提出精准营养与个性化多维概念
项目概述：在2016年首次提出“精准营养”作为核心研发战略，并于2021年发布《精准营养白皮书》，推出国内首款个性化定制维生素概念产品，为精准营养领域的研发带来突破。该产品在精准营养领域的产业化走在行业前列。
4.2 引入量化健康概念“内稳态”
项目概述：首次将“内稳态”量化健康概念引入中国，并得到学术界重视。中科院启动“多维大数据驱动的中国人群精准健康研究”项目，担任子课题负责人，致力于建立“内稳态指数”体系，推动精准营养健康评估、预测和干预体系的构建。
4.3 干血斑检测技术开发
项目概述：带领团队开发了一种快速、简便、低成本的干血斑检测方法，用于测定人体内的多种生化指标（如NAD+、同型半胱氨酸、脂质过氧化产物等），为精准营养和健康评估提供依据，推动了干血斑检测技术在营养健康评估中的应用。
【参编教材与论著】
《老年健康信息咨询师培训教材》
《精准营养白皮书—精准营养研究与产业转化趋势》
《营养生物技术与转化应用》
《中老年人专属营养与健康》
【获奖情况】
2017年珠海市高层次人才(2017年-2021年)；
2020年度广东省食品行业科技创新发展卓越工作者；
2021年度珠海市科技创新领军人物；
2023年度中国发明协会发明创业奖创新二等奖；
广东省外籍高层次人才
【社会兼职】 
中国营养学会精准营养分会主任委员；
国家卫健委全国老龄健康专家库专家；
国家心血管病专家委员会健康生活方式医学专业委员会委员；
中国食品科学技术学会益生菌分会常务理事；
中国食品药品企业质量安全促进会功能食品分会专家委员；
中国老年保健医学研究会理事会理事；
中国老年保健医学研究会老年健康科技创新分会秘书长；
中国老年保健医学研究会健康标准工作委员会副主任委员；
中国营养学会基础营养分会常务委员；
中国营养学会营养与保健食品分会常务委员；
中国微生物学会工业微生物学专业委员会委员；
中国营养保健食品协会保健食品研发专业委员会副主任委员；
中国食品科学技术学会新质蛋白专业委员会；
中华预防医学会老龄健康与医养结合工作委员会委员；
健康中国研究中心老龄健康专家委员会委员；
广东省食品行业协会副会长；
广东省营养学会常务理事；
广东省毒理学会常务理事；
广东省市场监督局审评认证技术协会保健食品专业委员会副主任委员；
南昌大学食品学院硕士研究生兼职导师；
暨南大学生物与医药硕士研究生实践指导老师；
深圳大学生命与海洋科学学院荣誉客座教授