【职称】
 教授、研究员

【学位/学历】
 博士 

【学习经历】 
2011.05 – 2015.12 University of Lübeck(德)  免疫学 博士
2007.09 – 2010.07 中国疾病预防控制中心 免疫学  硕士
2002.09 – 2007.09 天津医科大学 预防医学 本科/学士

【工作经历】 
2024.02 至今  广西壮族自治区人民医院（广西医学科学院）
                临床人工智能工作组副组长、心血管疾病研究所研究员
2018.12 – 2024.11 右江民族医学院 基础医学院 免疫学学术带头人
2016.02 – 2018.11 Georgia State University (美)、Univerisity of Münster（德） 博士后

【研究方向及兴趣】 
1.基于数学和算法，以实际应用为导向，开发精细模型、推进统计推断、优化算法以处理高维数据并模拟分子动力学和免疫过程。
2.结合生物数学和信息学，开发应用级别的临床工具，如药方审验系统、智能门诊平台和自动化病历审核工具等，集中于算法效率和严谨性，提升医疗场景中的诊断准效能、辅助决策。常用开发语言为C++、Go、R语言、Python和JavaScript.

【论文代表作（近五年）】 
1: Qin Y, Wang X, Zhang X, Nong L, Hou Q, Chen Y, Li Y, Lin W, Mao X, Wu K, Nong W, Wang T, Meng L, Song J. Retinoic acid modulates peritoneal macrophage function and distribution to enhance antibacterial defense during inflammation. Front Nutr. 2025 Apr 30;12:1545720. doi: 10.3389/fnut.2025.1545720. PMID:40370796; PMCID: PMC12075188.
2: Huang P, Meng L, Pang J, Huang H, Ma J, He L, Lin X. Long Noncoding RNA SNHG12 Regulates Ischemia/reperfusion (I/R)-mediated Acute Kidney Injury (AKI) Through miR-129-1-3p/Ubiquitin Specific Peptidase 25 axis. Appl Biochem Biotechnol. 2025 May;197(5):2958-2978. doi: 10.1007/s12010-024-05148-2. Epub 2025 Jan 16. PMID: 39820927.
3: Zhou Y, Yang Y, Wang B, Chen W, Wei Y, Wu R, Meng L, Lyu L. Discovery of ferroptosis-related genes in renal ischemia reperfusion and evaluate the potential impact on kidney transplantation. Front Immunol. 2024 Sep 6;15:1394477. doi: 10.3389/fimmu.2024.1394477. PMID: 39308866; PMCID:PMC11412852.
4: Meng L, Tang Q, Zhou W, Wei D, Zhao J, Shen J, Yang M, He S, Huang S, Qin Y, Song J, Luo L, Tang Q. Contributions of T Cell Signaling for Wound Healing. J Burn Care Res. 2024 Nov 14;45(6):1513-1519. doi: 10.1093/jbcr/irae151. PMID: 39110034.
5: Chen Y, Shen J, Ling C, Liang Z, Huang S, Lin W, Qin Y, Meng L, Luo Y. Exploring the role of CD8+ T cells in clear renal cell carcinomametastasis. FEBS Open Bio. 2024 Jul;14(7):1205-1217. doi:
10.1002/2211-5463.13819. Epub 2024 Jun 13. PMID: 38872260; PMCID: PMC11216920.
6: Huang P, Meng L, Pang J, Huang H, Ma J, He L, Lin X. miR-208a-3p regulated by circUQCRC2 suppresses ischemia/reperfusion-induced acute kidney injury by inhibiting CELF2-mediated tubular epithelial cell apoptosis, inflammation and ferroptosis. Shock. 2024 Jun 1;61(6):942-950. doi: 10.1097/SHK.0000000000002339. Epub 2024 Apr 26. PMID: 38664873.
7: Huang P, Meng L, Pang J, Huang H, Ma J, He L, Amani P. Development of a high- performance label-free electrochemical immunosensor for early cancer diagnosis using anti-CEA/Ag-MOF/GO/GCE nanocomposite. Environ Res. 2023 Dec 1;238(Pt2):117178. doi: 10.1016/j.envres.2023.117178. Epub 2023 Sep 20. PMID: 37734580.
8: Wang Z, Shen J, Ye K, Zhao J, Huang S, He S, Qin Y, Meng L, Wang J, Song J. Neutrophil-Derived IL-6 Potentially Drives Ferroptosis Resistance in B Cells in Lupus Kidney. Mediators Inflamm. 2023 May 27;2023:9810733. doi:10.1155/2023/9810733. PMID: 37273451; PMCID: PMC10239302.
9: Yan X, Meng L, Zhang X, Deng Z, Gao B, Zhang Y, Yang M, Ma Y, Zhang Y, Tu K, Zhang M, Xu Q. Reactive oxygen species-responsive nanocarrier ameliorates murine colitis by intervening colonic innate and adaptive immune responses. Mol Ther. 2023 May 3;31(5):1383-1401. doi: 10.1016/j.ymthe.2023.02.017. Epub 2023 Feb 28.PMID: 36855303; PMCID: PMC10188638.
10: Lv C, Yang D, Zhang D, Shen J, Wang Z, He S, Meng L, Song J, Zhao J. The Expression of ARMCX1  in Gastric Cancer Contributes to Prognosis and Influences Chemotherapy. J Immunol Res. 2023 Jan 23;2023:2623317. doi:10.1155/2023/2623317. PMID: 36726491; PMCID: PMC9886469.
11: Li X, Han G, Zhao J, Huang X, Feng Y, Huang J, Lan X, Huang X, Wang Z, Shen J, He S, Li Q, Song J, Wang J, Meng L. Intestinal flora induces depression by mediating the dysregulation of cerebral cortex gene expression and regulating the metabolism of stroke patients. Front Mol Biosci. 2022 Nov 30;9:865788. doi:10.3389/fmolb.2022.865788. PMID: 36533076; PMCID: PMC9748625.
12: Xu FT, Ling Y, Wei HX, Meng L, Yin D, Lai ZH, Huang Y, Huang X, Li HY, Luo QW, Song J, Tang Q, Li HM. BMSC exosomes deliver JKAP to restore Th17/Treg balance via AKT/ERK, alleviating rheumatoid arthritis. iScience. 2025 Jun 6;28(7):112832. doi: 10.1016/j.isci.2025.112832. PMID: 40687841; PMCID:PMC12271589.
13: Lin W, Tang L, Zhuo C, Mao X, Shen J, Huang S, Li S, Qin Y, Liao J, Chen Y, Zhang X, Li Y, Song J, Meng L, Dong X, Li Y. scRNA-Seq Analysis Revealed CAFs Regulating HCC Cells via PTN Signaling. J Hepatocell Carcinoma. 2024 Nov18;11:2269-2281. doi: 10.2147/JHC.S493675. PMID: 39582814; PMCID: PMC11583788.
14: Meng L, Lu H, Li Y, Zhao J, He S, Wang Z, Shen J, Huang H, Xiao J, Sooranna SR, Song J. Human papillomavirus infection can alter the level of tumour stemness and T cell infiltration in patients with head and neck squamous cell carcinoma. Front Immunol. 2022 Nov 7;13:1013542. doi: 10.3389/fimmu.2022.1013542. PMID: 36420261; PMCID: PMC9676257.
15: Jiang Y, Gong Q, Huang J, Gong Y, Tang Q, Wei D, Tang Q, Zhao J, Song J, Meng L. ADAM-10 Regulates MMP-12 during Lipopolysaccharide-Induced Inflammatory Response in Macrophages. J Immunol Res. 2022 Sep 16;2022:3012218. doi: 10.1155/2022/3012218. PMID: 36157882; PMCID: PMC9507754.
16: Liang Z, Nong F, Zhao J, Wei D, Tang Q, Song J, Meng L. Heterogeneity in NK Cell Subpopulations May Be Involved in Kidney Cancer Metastasis. J Immunol Res. 2022 Aug 22;2022:6378567. doi: 10.1155/2022/6378567. PMID: 36046723; PMCID:PMC9424044.
17: Wang J, Huang F, Zhao J, Huang P, Tan J, Huang M, Ma R, Xiao Y, He S, Wang Z, Shen J, Lu H, Meng L. Tumor-Infiltrated CD8+ T Cell 10-Gene Signature Related to Clear Cell Renal Cell Carcinoma Prognosis. Front Immunol. 2022 Jun
24;13:930921. doi: 10.3389/fimmu.2022.930921. PMID: 35812454; PMCID: PMC9263606. 18: Meng L, Chen S, Shi G, He S, Wang Z, Shen J, Wang J, Sooranna SR, Zhao J, Song J. Use of Single Cell Transcriptomic Techniques to Study the Role of High-Risk Human Papillomavirus Infection in Cervical Cancer. Front Immunol. 2022 Jun 13;13:907599. doi: 10.3389/fimmu.2022.907599. PMID: 35769468; PMCID: PMC9236134.
19: Huang J, Li X, Zhao J, Chen H, Yun Y, Yang G, Jiang Y, Pan Y, Yuan S, Huang J, Su L, Wu Y, Lu D, Xu A, Meng L. Association of BIRC5 Gene Polymorphism with the Collateral Circulation and Severity of Large Artery Atherosclerotic Stroke. Int J Clin Pract. 2022 Jan 31;2022:9177545. doi: 10.1155/2022/9177545. PMID:35685607; PMCID: PMC9159164.
20: Yu J, Li H, Zhao J, Huang Y, Liu C, Yang P, Lu D, Song J, Meng L. Alterations of the Gut Microbiome in Chinese Zhuang Ethnic Patients with Sepsis.Mediators Inflamm. 2022 May 20;2022:2808249. doi: 10.1155/2022/2808249. PMID:35633656; PMCID: PMC9142305.
21: Tian R, Hong J, Zhao J, Zhou D, Liu Y, Jiao Z, Song J, Zhang Y, Meng L, Yu M. Overall Structural Alteration of Gut Microbiota and Relationships with Risk Factors in Patients with Metabolic Syndrome Treated with Inulin Alone and with Other Agents: An Open-Label Pilot Study. Mediators Inflamm. 2022 May 19;2022:2078520. doi: 10.1155/2022/2078520. PMID: 35633654; PMCID: PMC9136633.
22: Ma Y, Li Y, Guo P, Zhao J, Qin Q, Wang J, Liang Z, Wei D, Wang Z, Shen J, He S, Tang Q, Lu G, Shi G, Meng L. Endothelial Cells Potentially Participate in the Metastasis of Triple-Negative Breast Cancer. J Immunol Res. 2022 Feb 27;2022:5412007. doi: 10.1155/2022/5412007. PMID: 35265720; PMCID: PMC8898858.
23: Wang J, Huang M, Huang P, Zhao J, Tan J, Huang F, Ma R, Xiao Y, Deng G, Wei L, Wei Q, Wang Z, He S, Shen J, Sooranna S, Meng L, Song J. The Identification of a Tumor Infiltration CD8+ T-Cell Gene Signature That Can Potentially Improve the Prognosis and Prediction of Immunization Responses in Papillary Renal Cell Carcinoma. Front Oncol. 2021 Nov 10;11:757641. doi: 10.3389/fonc.2021.757641. PMID: 34858833; PMCID: PMC8631402.
24: Wu Y, Meng L, Cai K, Zhao J, He S, Shen J, Wei Q, Wang Z, Sooranna S, Li H, Song J. A Tumor-Infiltration CD8+ T Cell-Based Gene Signature for Facilitating the Prognosis and Estimation of Immunization Responses in HPV+ Head and Neck Squamous Cell Cancer. Front Oncol. 2021 Sep 28;11:749398. doi: 10.3389/fonc.2021.749398. PMID: 34650931; PMCID: PMC8507562.
25: Meng L, Qin H, Zhao J, He S, Wei Q, Wang Z, Shen J, Sooranna S, Song J. Transcriptomic Signatures of Airway Epithelium Infected With SARS-CoV-2: A Balance Between Anti-infection and Virus Load. Front Cell Dev Biol. 2021 Aug 23;9:735307. doi: 10.3389/fcell.2021.735307. PMID: 34497809; PMCID: PMC8419361.
26: Yang F, Zhao J, Luo X, Li T, Wang Z, Wei Q, Lu H, Meng Y, Cai K, Lu L, Lu Y, Chen L, Sooranna SR, Luo L, Song J, Meng L. Transcriptome Profiling Reveals B-Lineage Cells Contribute to the Poor Prognosis and Metastasis of Clear Cell Renal Cell Carcinoma. Front Oncol. 2021 Aug 12;11:731896. doi:10.3389/fonc.2021.731896. PMID: 34485161; PMCID: PMC8416254.
27: Wei HP, Zhan S, Zhu QA, Chen ZJ, Feng X, Chen JY, Zhang QL, Zhao J, Meng L. Genome-Wide Expression Difference of MicroRNAs in Basal Cell Carcinoma. J Immunol Res. 2021 Aug 4;2021:7223500. doi: 10.1155/2021/7223500. PMID: 34395634; PMCID: PMC8357504.
28: Meng L, Tang Q, Zhao J, Wang Z, Wei L, Wei Q, Yin L, Luo S, Song J. S100A9 Derived From Myeloma Associated Myeloid Cells Promotes TNFSF13B/TNFRSF13B-Dependent Proliferation and Survival of Myeloma Cells. Front Oncol. 2021 Jun 3;11:691705. doi: 10.3389/fonc.2021.691705. PMID: 34150664;PMCID: PMC8210673.
29: Huang P, Meng L, Tan J, Gu X, Huang M, Huang F, Ma R, Wang J. S3-2, a novel long-lasting oxyntomodulin derivative, exerts improvement on diabesity and renal injury through activating GLP-1 and glucagon receptors. Life Sci. 2021 Apr 1;270:119136. doi: 10.1016/j.lfs.2021.119136. Epub 2021 Jan 27. PMID: 33508289.
30: Li Y, Zhang Y, Zhang S, Huang D, Li B, Liang G, Wu Y, Jiang Q, Li L, Lin C, Wei Z, Meng L. circRNA circARNT2 Suppressed the Sensitivity of Hepatocellular Carcinoma Cells to Cisplatin by Targeting the miR-155-5p/PDK1 Axis. Mol Ther Nucleic Acids. 2020 Sep 3;23:244-254. doi: 10.1016/j.omtn.2020.08.037. PMID:33425483; PMCID: PMC7772525.
31: Meng L, Huang Q, Li X, Liang P, Li Y, Huang X, Zhao J, Chen Q, Qiu R, Li L, Jian C, Yao H, Huang J, Tang X, Wang Z, Wei Z, Wu J, Wei L, Wei Q, Tang Q, Huang L, Wei J, Lu D, Luo Q, Xie K, Ouyang Y, Chen J, Li G, Luo L, He L, Zhuo C, Xu A, Meng L. Genes Induced by Panax Notoginseng in a Rodent Model of Ischemia-Reperfusion Injury. J Immunol Res. 2020 Nov 25;2020:8873261. doi: 10.1155/2020/8873261. PMID: 33294469; PMCID: PMC7714582.
32: Wang J, Luo P, Zhao J, Tan J, Huang F, Ma R, Huang P, Huang M, Huang Y, Wei Q, Wei L, Wang Z, Meng L. Profiling the Resident and Infiltrating Monocyte/Macrophages during Rejection following Kidney Transplantation. J Immunol Res. 2020 Sep 21;2020:5746832. doi: 10.1155/2020/5746832. PMID: 33015198; PMCID: PMC7525314.
33: Meng L, Almeida LN, Clauder AK, Lindemann T, Luther J, Link C, Hofmann K, Kulkarni U, Wong DM, David JP, Manz RA. Bone Marrow Plasma Cells Modulate Local Myeloid-Lineage Differentiation via IL-10. Front Immunol. 2019 May 31;10:1183.doi: 10.3389/fimmu.2019.01183. PMID: 31214168; PMCID: PMC6555095.

【研究项目】 
（1）广西壮族自治区人民医院，高层次人才启动项目, YKY-GCRC-202501， 低分化非浸润性膀胱癌组织中性粒细胞生物多样性对血管内皮细胞影响的研究， 2024.02-2027.02，在研，主持
（2）广西科学技术厅，广西重点研发项目, 2023AB22092， 广西地区特定环境暴露对膜性肾病的作用研究， 2024-05 至 2027-04, 在研， 参与
（3）广西科学技术厅，广西科技基地和人才专项，桂科AD22035101，重大传染性疾病重症救治临床医学研究中心，2022.04-2025.04 在研，参与
（4）百色市科学技术局， 区域多发病联合专项， 百科20224145， 膜性肾病免疫复合物沉积引起足细胞损伤的分子机制， 2022-12 至 2025-12，在研, 主持
（5）国家自然科学基金委员会， 地区科学基金项目， 31960728， 外泌体miRNA靶向组蛋白（去）乙酰化酶调控中华绒螯蟹精子发生的机制， 2020-01-01 至 2023-12-31,  结题， 参与
（6）广西科学技术厅， 广西自然科学基金（面上项目）， 2020GXNSFAA259050，中性粒细胞在狼疮性肾炎中对浆细胞功能调控分子机制的研究， 2020-01 至 2022-12，  结题， 主持
  
【获奖情况】 
中国疾病预防控制中心 优秀毕业生

【社会兼职】  
1. SCI杂志《Journal of Immunology Research》 客座编辑  影响因子4.818
2. SCI杂志《Oncology Research》 客座编辑  影响因子3.10
3. 中国民族医药学会微创技术分会 常务理事
4. 中国性病艾滋病防治协会艾滋病检测与促进社会应用专业委员会 委员
5. 中国法学会广西分会 理事
6. 广西生物信息学学会理事